TY - GEN AB - Cancer cachexia is a co-morbidity highly prevalent in pancreatic ductal adenocarcinoma (PDAC) patients and results in a decreased quality of life.This work expands on prior knowledge of IL-6 in cancer cachexia, implicates impaired hepatic metabolism as an early event in cachexia progression, and highlights the liver as a target for potential interventions in cachexia treatment. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AU - Arneson-Wissink, Paige AU - Mendez, Heike AU - Pelz, Katherine AU - Dickie, Jessica AU - Marks, Daniel AU - Grossberg, Aaron DA - 2023-08-22 DO - 10.6083/bpxhc41625 DO - doi ID - 41625 KW - Pancreatic Neoplasms KW - Cachexia KW - STAT3 Transcription Factor KW - Interleukin-6 KW - Diet, Ketogenic KW - pancreatic ductal adenocarcinoma KW - diet KW - pancreatic cancer KW - liver L1 - https://digitalcollections.ohsu.edu/record/41625/files/ResearchWeek.2023.Arneson.Paige.pdf L2 - https://digitalcollections.ohsu.edu/record/41625/files/ResearchWeek.2023.Arneson.Paige.pdf L4 - https://digitalcollections.ohsu.edu/record/41625/files/ResearchWeek.2023.Arneson.Paige.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/41625/files/ResearchWeek.2023.Arneson.Paige.pdf N2 - Cancer cachexia is a co-morbidity highly prevalent in pancreatic ductal adenocarcinoma (PDAC) patients and results in a decreased quality of life.This work expands on prior knowledge of IL-6 in cancer cachexia, implicates impaired hepatic metabolism as an early event in cachexia progression, and highlights the liver as a target for potential interventions in cachexia treatment. PB - Oregon Health and Science University PY - 2023-08-22 T1 - Inflammatory signaling in the liver drives early metabolic disruption in pancreatic cancer cachexia TI - Inflammatory signaling in the liver drives early metabolic disruption in pancreatic cancer cachexia UR - https://digitalcollections.ohsu.edu/record/41625/files/ResearchWeek.2023.Arneson.Paige.pdf Y1 - 2023-08-22 ER -