000041625 001__ 41625
000041625 005__ 20240410100338.0
000041625 0247_ $$2doi$$a10.6083/bpxhc41625
000041625 037__ $$aIR
000041625 041__ $$aeng
000041625 245__ $$aInflammatory signaling in the liver drives early metabolic disruption in pancreatic cancer cachexia
000041625 260__ $$bOregon Health and Science University
000041625 269__ $$a2023-08-22
000041625 336__ $$aAbstract
000041625 520__ $$aCancer cachexia is a co-morbidity highly prevalent in pancreatic ductal adenocarcinoma (PDAC) patients and results in a decreased quality of life.This work expands on prior knowledge of IL-6 in cancer cachexia, implicates impaired hepatic metabolism as an early event in cachexia progression, and highlights the liver as a target for potential interventions in cachexia treatment.
000041625 540__ $$fCC BY
000041625 542__ $$fIn copyright - joint owners
000041625 650__ $$aPancreatic Neoplasms$$023517
000041625 650__ $$aCachexia$$015945
000041625 650__ $$aSTAT3 Transcription Factor$$036557
000041625 650__ $$aInterleukin-6$$028703
000041625 650__ $$aDiet, Ketogenic$$038297
000041625 6531_ $$apancreatic ductal adenocarcinoma
000041625 6531_ $$adiet
000041625 6531_ $$apancreatic cancer
000041625 6531_ $$aliver
000041625 692__ $$aBrenden-Colson Center for Pancreatic Care$$041379
000041625 7001_ $$aArneson-Wissink, Paige$$uOregon Health and Science University$$041354
000041625 7001_ $$aMendez, Heike$$uOregon Health and Science University$$041354
000041625 7001_ $$aPelz, Katherine$$uOregon Health and Science University$$041354
000041625 7001_ $$aDickie, Jessica$$uOregon Health and Science University$$041354
000041625 7001_ $$aMarks, Daniel$$uOregon Health and Science University$$041354
000041625 7001_ $$aGrossberg, Aaron$$uOregon Health and Science University$$041354
000041625 711__ $$aResearch Week$$uOregon Health and Science University$$d2023
000041625 8564_ $$9cfc02ef5-0ae1-4b49-b90d-417ff55de050$$s82523$$uhttps://digitalcollections.ohsu.edu/record/41625/files/ResearchWeek.2023.Arneson.Paige.pdf
000041625 950__ $$agorton@ohsu.edu
000041625 980__ $$aResearch Week
000041625 981__ $$aPublished