@article{ETD,
      school = {Ph.D.},
      author = {Doha, Zinab O.M.},
      url = {http://digitalcollections.ohsu.edu/record/41627},
      title = {Modeling the heterogeneity and targeting the resistant  mechanism of triple-negative breast cancer},
      publisher = {Oregon Health and Science University},
      abstract = {Triple-negative breast cancer (TNBC) is a highly  aggressive breast cancer subtype characterized by a  remarkable molecular heterogeneity. Currently, there are no  effective druggable targets and advanced preclinical models  of human disease. This thesis investigates the role of MYC,  a common TNBC deregulated oncogene, in TNBC  microenvironment complexities, with a focus on oncogenic  transformation of MYC driven therapeutic resistance as well  as the functional consequences of targeting MYC in TNBC.  Such understanding potentiates a critical need in the field  to identify effective targeted therapy for TNBC and  establishes a foundation for translating preclinical  findings into effective human clinical trials.},
      number = {ETD},
      doi = {https://doi.org/10.6083/bpxhc41627},
      recid = {41627},
      address = {2023-08-23},
}