TY  - GEN
N2  - Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective druggable targets and advanced preclinical models of human disease. This thesis investigates the role of MYC, a common TNBC deregulated oncogene, in TNBC microenvironment complexities, with a focus on oncogenic transformation of MYC driven therapeutic resistance as well as the functional consequences of targeting MYC in TNBC. Such understanding potentiates a critical need in the field to identify effective targeted therapy for TNBC and establishes a foundation for translating preclinical findings into effective human clinical trials.
DO  - 10.6083/bpxhc41627
DO  - doi
AB  - Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective druggable targets and advanced preclinical models of human disease. This thesis investigates the role of MYC, a common TNBC deregulated oncogene, in TNBC microenvironment complexities, with a focus on oncogenic transformation of MYC driven therapeutic resistance as well as the functional consequences of targeting MYC in TNBC. Such understanding potentiates a critical need in the field to identify effective targeted therapy for TNBC and establishes a foundation for translating preclinical findings into effective human clinical trials.
AD  - Oregon Health and Science University
T1  - Modeling the heterogeneity and targeting the resistant mechanism of triple-negative breast cancer
ED  - Sears, Rosalie
ED  - Advisor
DA  - 2023-08-23
AU  - Doha, Zinab O.M.
L1  - https://digitalcollections.ohsu.edu/record/41627/files/Doha.Zinab.2023.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-08-23
ID  - 41627
L4  - https://digitalcollections.ohsu.edu/record/41627/files/Doha.Zinab.2023.pdf
KW  - Triple Negative Breast Neoplasms
KW  - Genes, Tumor Suppressor
KW  - Breast Neoplasms
KW  - tnbc
KW  - parpi
KW  - myc proteins
KW  - pp2a
TI  - Modeling the heterogeneity and targeting the resistant mechanism of triple-negative breast cancer
Y1  - 2023-08-23
L2  - https://digitalcollections.ohsu.edu/record/41627/files/Doha.Zinab.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/41627/files/Doha.Zinab.2023.pdf
UR  - https://digitalcollections.ohsu.edu/record/41627/files/Doha.Zinab.2023.pdf
ER  -