000041627 001__ 41627
000041627 005__ 20240124114339.0
000041627 0247_ $$2doi$$a10.6083/bpxhc41627
000041627 037__ $$aETD
000041627 041__ $$aeng
000041627 245__ $$aModeling the heterogeneity and targeting the resistant mechanism of triple-negative breast cancer
000041627 260__ $$bOregon Health and Science University
000041627 269__ $$a2023-08-23
000041627 336__ $$aDissertation
000041627 502__ $$bPh.D.
000041627 502__ $$gBiomedical Sciences
000041627 520__ $$aTriple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective druggable targets and advanced preclinical models of human disease. This thesis investigates the role of MYC, a common TNBC deregulated oncogene, in TNBC microenvironment complexities, with a focus on oncogenic transformation of MYC driven therapeutic resistance as well as the functional consequences of targeting MYC in TNBC. Such understanding potentiates a critical need in the field to identify effective targeted therapy for TNBC and establishes a foundation for translating preclinical findings into effective human clinical trials.
000041627 540__ $$fCC BY
000041627 542__ $$fIn copyright - single owner
000041627 650__ $$aTriple Negative Breast Neoplasms$$040478
000041627 650__ $$aGenes, Tumor Suppressor$$028915
000041627 650__ $$aBreast Neoplasms$$015809
000041627 6531_ $$atnbc
000041627 6531_ $$aparpi
000041627 6531_ $$amyc proteins
000041627 6531_ $$app2a
000041627 691__ $$aSchool of Medicine$$041369
000041627 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000041627 7001_ $$aDoha, Zinab O.M.$$uOregon Health and Science University$$041354
000041627 7201_ $$aSears, Rosalie$$uOregon Health and Science University$$041354$$eAdvisor$$7Personal
000041627 8564_ $$9a241f97e-270e-4167-b8f7-bf7382ef5162$$s16573713$$uhttps://digitalcollections.ohsu.edu/record/41627/files/Doha.Zinab.2023.pdf
000041627 909CO $$ooai:digitalcollections.ohsu.edu:41627$$pstudent-work
000041627 980__ $$aTheses and Dissertations
000041627 981__ $$aPublished$$b2023-09-08