TY - GEN AB - The oral microbiome has co-evolved and coexisted in a symbiotic relationship within their own ecology and with the host. Understanding the oral ecosystem and how it promotes a balanced microbiome, is essential to effectively maintain or restore oral health. Of over 700 bacterial taxa, commensals Streptococcus and Corynebacterium are two of the most prevalent members of the oral microbiome. Surprisingly, the inter-species interactions between both commensals and the effect of such interactions on dental diseases have never been investigated. Therefore, in this study, we aim to understand the molecular mechanism(s) between different taxa interactions, in particularly, Corynebacterium durum and Streptococcus sanguinis, and the implications on oral diseases. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - University of Talca. Chile AU - Treerat, June AU - Anderson, David AU - Giacaman, Rodrigo A. DA - 2023-08-23 DO - 10.6083/bpxhc41630 DO - doi ID - 41630 KW - Glycerol Kinase KW - Fatty Acids KW - oral microbiome KW - glycerol dehydrogenase KW - membrane vesicles KW - symbiotic interaction L1 - https://digitalcollections.ohsu.edu/record/41630/files/ResearchWeek.2023.Treerat.June.pdf L2 - https://digitalcollections.ohsu.edu/record/41630/files/ResearchWeek.2023.Treerat.June.pdf L4 - https://digitalcollections.ohsu.edu/record/41630/files/ResearchWeek.2023.Treerat.June.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/41630/files/ResearchWeek.2023.Treerat.June.pdf N2 - The oral microbiome has co-evolved and coexisted in a symbiotic relationship within their own ecology and with the host. Understanding the oral ecosystem and how it promotes a balanced microbiome, is essential to effectively maintain or restore oral health. Of over 700 bacterial taxa, commensals Streptococcus and Corynebacterium are two of the most prevalent members of the oral microbiome. Surprisingly, the inter-species interactions between both commensals and the effect of such interactions on dental diseases have never been investigated. Therefore, in this study, we aim to understand the molecular mechanism(s) between different taxa interactions, in particularly, Corynebacterium durum and Streptococcus sanguinis, and the implications on oral diseases. PB - Oregon Health and Science University PY - 2023-08-23 T1 - Commensal glycerol metabolism determines oral niche development TI - Commensal glycerol metabolism determines oral niche development UR - https://digitalcollections.ohsu.edu/record/41630/files/ResearchWeek.2023.Treerat.June.pdf Y1 - 2023-08-23 ER -