@article{IR,
      author = {Singh, Prem and Demessie, Ananiya A. and Park, Youngrong  and Moses, Abraham S. and Korzun, Tetiana and Sabei, Fahad  Y. and Albarqi, Hassan A. and Campos, Leonardo and Wyatt,  Cory R. and Farsad, Khashayar and Dhagat, Pallavi and Sun,  Conroy and Taratula, Olena "Oleh" R.},
      url = {http://digitalcollections.ohsu.edu/record/41877},
      title = {An advanced thermal decomposition method for the synthesis  of novel cobalt-doped core (magnetite) – shell  (maghemite) iron oxide nanoparticles with ultrahigh heating  efficiency for systemic magnetic hyperthermia},
      publisher = {Oregon Health and Science University},
      abstract = {Owing to the low heating efficiency of currently available  magnetic nanoparticles, it is challenging to reach  therapeutic temperatures above 44 0C in tumors that are  generally difficult to access after systemic delivery of  nanoparticles at clinical dosage (10 mg kg-1). In order to  solve this problem, we have developed an advanced thermal  decomposition method for the synthesis of novel  cobalt-doped core (magnetite) – shell (maghemite) iron  oxide nanoparticles (Co-Fe3O4/γ-Fe2O3) with an ultrahigh  ILP of 48.0 nH m2 kg-1. Our in vivo research shows that  these nanoparticles containing a cancer-targeting peptide  are biocompatible and accumulate well in ovarian cancer  grafts after being administered systemically at a  concentration of 4 mg kg-1. When exposed to an external AMF  (420 kHz, 26.9 kA m-1), the delivered nanoparticles elevate  temperature in both subcutaneous and metastatic cancer  tumors to 50 0C.  This newly developed synthesis method can  be used for the synthesis of both non-doped core-shell  nanoparticles and core-shell nanoparticles doped with  different metals (e.g., Ni, Co). As a result, this strategy  could be extended to the development of novel nanoparticles  with even greater heating performance, further advancing  systemic magnetic hyperthermia for cancer treatment.},
      number = {IR},
      doi = {https://doi.org/10.6083/bpxhc41877},
      recid = {41877},
      address = {2023-09-11},
}