000041877 001__ 41877 000041877 005__ 20240327113759.0 000041877 0247_ $$2doi$$a10.6083/bpxhc41877 000041877 037__ $$aIR 000041877 041__ $$aeng 000041877 245__ $$aAn advanced thermal decomposition method for the synthesis of novel cobalt-doped core (magnetite) – shell (maghemite) iron oxide nanoparticles with ultrahigh heating efficiency for systemic magnetic hyperthermia 000041877 260__ $$bOregon Health and Science University 000041877 269__ $$a2023-09-11 000041877 336__ $$aAbstract 000041877 520__ $$aOwing to the low heating efficiency of currently available magnetic nanoparticles, it is challenging to reach therapeutic temperatures above 44 0C in tumors that are generally difficult to access after systemic delivery of nanoparticles at clinical dosage (10 mg kg-1). In order to solve this problem, we have developed an advanced thermal decomposition method for the synthesis of novel cobalt-doped core (magnetite) – shell (maghemite) iron oxide nanoparticles (Co-Fe3O4/γ-Fe2O3) with an ultrahigh ILP of 48.0 nH m2 kg-1. Our in vivo research shows that these nanoparticles containing a cancer-targeting peptide are biocompatible and accumulate well in ovarian cancer grafts after being administered systemically at a concentration of 4 mg kg-1. When exposed to an external AMF (420 kHz, 26.9 kA m-1), the delivered nanoparticles elevate temperature in both subcutaneous and metastatic cancer tumors to 50 0C. This newly developed synthesis method can be used for the synthesis of both non-doped core-shell nanoparticles and core-shell nanoparticles doped with different metals (e.g., Ni, Co). As a result, this strategy could be extended to the development of novel nanoparticles with even greater heating performance, further advancing systemic magnetic hyperthermia for cancer treatment. 000041877 540__ $$fCC BY 000041877 542__ $$fIn copyright - joint owners 000041877 650__ $$aHyperthermia, Induced$$020544 000041877 650__ $$aOvarian Neoplasms$$023386 000041877 650__ $$aNanoparticles$$037592 000041877 650__ $$aFerric Compounds$$018968 000041877 6531_ $$amagnetic hyperthermia 000041877 6531_ $$aovarian cancer 000041877 6531_ $$alhrh peptides 000041877 6531_ $$aamf 000041877 6531_ $$aneoplasms 000041877 6531_ $$acancer 000041877 691__ $$aOHSU/OSU College of Pharmacy$$041367 000041877 692__ $$aDepartment of Pharmacology$$041441 000041877 7001_ $$aSingh, Prem$$uOregon Health and Science University$$041354 000041877 7001_ $$aDemessie, Ananiya A.$$uOregon Health and Science University$$041354 000041877 7001_ $$aPark, Youngrong$$uOregon Health and Science University$$041354 000041877 7001_ $$aMoses, Abraham S.$$uOregon Health and Science University$$041354 000041877 7001_ $$aKorzun, Tetiana$$uOregon Health and Science University$$041354 000041877 7001_ $$aSabei, Fahad Y.$$uOregon Health and Science University$$041354 000041877 7001_ $$aAlbarqi, Hassan A.$$uOregon Health and Science University$$041354 000041877 7001_ $$aCampos, Leonardo$$uOregon Health and Science University$$041354 000041877 7001_ $$aWyatt, Cory R.$$uOregon Health and Science University$$041354 000041877 7001_ $$aFarsad, Khashayar$$uOregon Health and Science University$$041354 000041877 7001_ $$aDhagat, Pallavi$$uOregon Health and Science University$$041354 000041877 7001_ $$aSun, Conroy$$uOregon Health and Science University$$041354 000041877 7001_ $$aTaratula, Olena "Oleh" R.$$uOregon Health and Science University$$041354 000041877 711__ $$aResearch Week$$uOregon Health and Science University$$d2023 000041877 8564_ $$90f0b30d8-bfc1-4c55-8bb2-167bb1128db5$$s343538$$uhttps://digitalcollections.ohsu.edu/record/41877/files/ResearchWeek.2023.Singh.Prem.pdf 000041877 980__ $$aResearch Week 000041877 981__ $$aPublished$$b2023-09-11