TY  - GEN
N2  - Acute kidney injury (AKI) is a widespread health problem, with increased incidence among hospitalized patients. The most common cause of AKI is ischemic injury, which targets the proximal tubule causing damage to kidney structure and function. Within ischemic AKI, overactivation of the renin angiotensin system (RAS) can drive pathologic changes. Angiotensin converting enzyme 2 (ACE2) is an integral part of the RAS and is highly expressed along the brush border of the proximal tubule (PT), where it acts to enzymatically degrade angiotensin II (AngII) and extinguish its effects. While several studies have examined the protective role ACE2 plays within chronic kidney disease and hypertension, less is known about ACE2 in acute injury. Here, we hypothesize that ACE2 overexpression is protective against AKI through local AngII metabolism and promotes recovery of renal function after AKI.
DO  - 10.6083/bpxhc41879
DO  - doi
AB  - Acute kidney injury (AKI) is a widespread health problem, with increased incidence among hospitalized patients. The most common cause of AKI is ischemic injury, which targets the proximal tubule causing damage to kidney structure and function. Within ischemic AKI, overactivation of the renin angiotensin system (RAS) can drive pathologic changes. Angiotensin converting enzyme 2 (ACE2) is an integral part of the RAS and is highly expressed along the brush border of the proximal tubule (PT), where it acts to enzymatically degrade angiotensin II (AngII) and extinguish its effects. While several studies have examined the protective role ACE2 plays within chronic kidney disease and hypertension, less is known about ACE2 in acute injury. Here, we hypothesize that ACE2 overexpression is protective against AKI through local AngII metabolism and promotes recovery of renal function after AKI.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - ACE2 overexpression mediates spatial distribution of pathologic features in acute  kidney injury
DA  - 2023-09-11
AU  - Emathinger, Jacqueline
AU  - Robertson, Joshua A.
AU  - Nelson, Jonathan W.
AU  - Hagen, Matthew W.
AU  - Andeen, Nicole K.
AU  - Kung, Vanderlene L.
AU  - Hutchens, Michael P.
AU  - Gurley, Susan B.
L1  - https://digitalcollections.ohsu.edu/record/41879/files/ResearchWeek.2023.Emathinger.Jacqueline.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-09-11
ID  - 41879
L4  - https://digitalcollections.ohsu.edu/record/41879/files/ResearchWeek.2023.Emathinger.Jacqueline.pdf
KW  - Angiotensin-Converting Enzyme 2
KW  - Acute Kidney Injury
KW  - Pathology
KW  - Nephrology
KW  - Kidney
KW  - renal ischemia reperfusion injury
KW  - chronic kidney disease
TI  - ACE2 overexpression mediates spatial distribution of pathologic features in acute  kidney injury
Y1  - 2023-09-11
L2  - https://digitalcollections.ohsu.edu/record/41879/files/ResearchWeek.2023.Emathinger.Jacqueline.pdf
LK  - https://digitalcollections.ohsu.edu/record/41879/files/ResearchWeek.2023.Emathinger.Jacqueline.pdf
UR  - https://digitalcollections.ohsu.edu/record/41879/files/ResearchWeek.2023.Emathinger.Jacqueline.pdf
ER  -