000041879 001__ 41879 000041879 005__ 20240327102957.0 000041879 0247_ $$2doi$$a10.6083/bpxhc41879 000041879 037__ $$aIR 000041879 041__ $$aeng 000041879 245__ $$aACE2 overexpression mediates spatial distribution of pathologic features in acute kidney injury 000041879 260__ $$bOregon Health and Science University 000041879 269__ $$a2023-09-11 000041879 336__ $$aAbstract 000041879 520__ $$aAcute kidney injury (AKI) is a widespread health problem, with increased incidence among hospitalized patients. The most common cause of AKI is ischemic injury, which targets the proximal tubule causing damage to kidney structure and function. Within ischemic AKI, overactivation of the renin angiotensin system (RAS) can drive pathologic changes. Angiotensin converting enzyme 2 (ACE2) is an integral part of the RAS and is highly expressed along the brush border of the proximal tubule (PT), where it acts to enzymatically degrade angiotensin II (AngII) and extinguish its effects. While several studies have examined the protective role ACE2 plays within chronic kidney disease and hypertension, less is known about ACE2 in acute injury. Here, we hypothesize that ACE2 overexpression is protective against AKI through local AngII metabolism and promotes recovery of renal function after AKI. 000041879 540__ $$fCC BY 000041879 542__ $$fIn copyright - joint owners 000041879 650__ $$aAngiotensin-Converting Enzyme 2$$013488 000041879 650__ $$aAcute Kidney Injury$$039113 000041879 650__ $$aPathology$$023652 000041879 650__ $$aNephrology$$022786 000041879 650__ $$aKidney$$021185 000041879 6531_ $$arenal ischemia reperfusion injury 000041879 6531_ $$achronic kidney disease 000041879 691__ $$aSchool of Medicine$$041369 000041879 692__ $$aDivision of Nephrology and Hypertension$$041464 000041879 7001_ $$aEmathinger, Jacqueline$$uOregon Health and Science University$$041354 000041879 7001_ $$aRobertson, Joshua A.$$uOregon Health and Science University$$041354 000041879 7001_ $$aNelson, Jonathan W.$$uOregon Health and Science University$$041354 000041879 7001_ $$aHagen, Matthew W.$$uOregon Health and Science University$$041354 000041879 7001_ $$aAndeen, Nicole K.$$uOregon Health and Science University$$041354 000041879 7001_ $$aKung, Vanderlene L.$$uOregon Health and Science University$$041354 000041879 7001_ $$aHutchens, Michael P.$$uOregon Health and Science University$$041354 000041879 7001_ $$aGurley, Susan B.$$uOregon Health and Science University$$041354 000041879 711__ $$aResearch Week$$uOregon Health and Science University$$d2023 000041879 8564_ $$9f6060527-2f36-48ca-a78f-3dd07cac2121$$s37275$$uhttps://digitalcollections.ohsu.edu/record/41879/files/ResearchWeek.2023.Emathinger.Jacqueline.pdf 000041879 980__ $$aResearch Week 000041879 981__ $$aPublished$$b2023-09-11