TY  - GEN
AB  - Bone defects can occur after trauma, infection, or oncologic resection and autologous bone grafting is the current treatment option. However, this method has its limitations in more severe injuries as it may cause infection and scarring at donor sites. Thus, developing biomaterials that are osteoinductive with live cells is essential for treating bone defects.   We are creating a bone-like structure that are biomineralized to the nanoscale level and embedded with human mesenchymal stem cells (hMSCs) that undergo osteogenic differentiation without any conventional supplements.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Visalakshan, Rahul M.
AU  - Sousa, Mauricio
AU  - Taheri, Anthony
AU  - Athirasala, Avathamsa
AU  - Bertassoni, Luiz
DA  - 2023-09-12
DO  - 10.6083/bpxhc41886
DO  - doi
ID  - 41886
KW  - Cell Culture Techniques
KW  - Tissue Engineering
KW  - Bioprinting
KW  - Microfluidics
KW  - Biomineralization
KW  - Osteogenesis
KW  - human bone regeneration
KW  - bone defects
KW  - human mesenchymal stem cells
L1  - https://digitalcollections.ohsu.edu/record/41886/files/ResearchWeek.2023.Visalakshan.Rahul.pdf
L2  - https://digitalcollections.ohsu.edu/record/41886/files/ResearchWeek.2023.Visalakshan.Rahul.pdf
L4  - https://digitalcollections.ohsu.edu/record/41886/files/ResearchWeek.2023.Visalakshan.Rahul.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/41886/files/ResearchWeek.2023.Visalakshan.Rahul.pdf
N2  - Bone defects can occur after trauma, infection, or oncologic resection and autologous bone grafting is the current treatment option. However, this method has its limitations in more severe injuries as it may cause infection and scarring at donor sites. Thus, developing biomaterials that are osteoinductive with live cells is essential for treating bone defects.   We are creating a bone-like structure that are biomineralized to the nanoscale level and embedded with human mesenchymal stem cells (hMSCs) that undergo osteogenic differentiation without any conventional supplements.
PB  - Oregon Health and Science University
PY  - 2023-09-12
T1  - Faster biomineralization and osteogenesis on-a-chip  using 3D bioprinting and microfluidics
TI  - Faster biomineralization and osteogenesis on-a-chip  using 3D bioprinting and microfluidics
UR  - https://digitalcollections.ohsu.edu/record/41886/files/ResearchWeek.2023.Visalakshan.Rahul.pdf
Y1  - 2023-09-12
ER  -