000041886 001__ 41886 000041886 005__ 20240405161401.0 000041886 0247_ $$2doi$$a10.6083/bpxhc41886 000041886 037__ $$aIR 000041886 041__ $$aeng 000041886 245__ $$aFaster biomineralization and osteogenesis on-a-chip using 3D bioprinting and microfluidics 000041886 260__ $$bOregon Health and Science University 000041886 269__ $$a2023-09-12 000041886 336__ $$aAbstract 000041886 520__ $$aBone defects can occur after trauma, infection, or oncologic resection and autologous bone grafting is the current treatment option. However, this method has its limitations in more severe injuries as it may cause infection and scarring at donor sites. Thus, developing biomaterials that are osteoinductive with live cells is essential for treating bone defects. We are creating a bone-like structure that are biomineralized to the nanoscale level and embedded with human mesenchymal stem cells (hMSCs) that undergo osteogenic differentiation without any conventional supplements. 000041886 540__ $$fCC BY 000041886 542__ $$fIn copyright - joint owners 000041886 650__ $$aCell Culture Techniques$$031208 000041886 650__ $$aTissue Engineering$$033051 000041886 650__ $$aBioprinting$$040002 000041886 650__ $$aMicrofluidics$$035383 000041886 650__ $$aBiomineralization$$012733 000041886 650__ $$aOsteogenesis$$023347 000041886 6531_ $$ahuman bone regeneration 000041886 6531_ $$abone defects 000041886 6531_ $$ahuman mesenchymal stem cells 000041886 691__ $$aSchool of Dentistry$$041368 000041886 692__ $$aDivision of Biomaterials and Biomechanics$$041456 000041886 692__ $$aDepartment of Restorative Dentistry$$041446 000041886 7001_ $$aVisalakshan, Rahul M.$$uOregon Health and Science University$$041354 000041886 7001_ $$aSousa, Mauricio$$uOregon Health and Science University$$041354 000041886 7001_ $$aTaheri, Anthony$$uOregon Health and Science University$$041354 000041886 7001_ $$aAthirasala, Avathamsa$$uOregon Health and Science University$$041354 000041886 7001_ $$aBertassoni, Luiz$$uOregon Health and Science University$$041354 000041886 711__ $$aResearch Week$$uOregon Health and Science University$$d2023 000041886 8564_ $$95dec9355-2a3a-4227-b153-0398950639f9$$s164595$$uhttps://digitalcollections.ohsu.edu/record/41886/files/ResearchWeek.2023.Visalakshan.Rahul.pdf 000041886 980__ $$aResearch Week 000041886 981__ $$aPublished$$b2023-09-13