TY  - GEN
AB  - Rett syndrome is a neurological disease due to loss-of-function mutations in the transcription factor, Methyl CpG binding protein 2 (MECP2). Because overexpression of endogenous MECP2 also causes disease, we have exploited a targeted RNA-editing approach to repair patient mutations where levels of MECP2 protein will never exceed endogenous levels.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Sinnamon, John R.
AU  - Jacobson, Michael E.
AU  - Yung, John F.
AU  - Fisk, Jenna R.
AU  - Jeng, Sophia
AU  - McWeeney, Shannon K.
AU  - Parmelee, Lindsay K.
AU  - Chan, Chi Ngai
AU  - Yee, Siu-Pok
AU  - Kragness, Sabrina
AU  - Mandel, Gail
DA  - 2023-09-13
DO  - 10.6083/bpxhc41889
DO  - doi
ID  - 41889
KW  - Rett Syndrome
KW  - Nervous System Diseases
KW  - Mutation
KW  - RNA Editing
KW  - Developmental Disabilities
KW  - Humans
KW  - Nervous System Diseases
KW  - Neurodevelopmental Disorders
KW  - Methyl-CpG-Binding Protein 2
KW  - MECP2
KW  - targeted RNA editing
L1  - https://digitalcollections.ohsu.edu/record/41889/files/ResearchWeek.2023.Yung.John.pdf
L2  - https://digitalcollections.ohsu.edu/record/41889/files/ResearchWeek.2023.Yung.John.pdf
L4  - https://digitalcollections.ohsu.edu/record/41889/files/ResearchWeek.2023.Yung.John.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/41889/files/ResearchWeek.2023.Yung.John.pdf
N2  - Rett syndrome is a neurological disease due to loss-of-function mutations in the transcription factor, Methyl CpG binding protein 2 (MECP2). Because overexpression of endogenous MECP2 also causes disease, we have exploited a targeted RNA-editing approach to repair patient mutations where levels of MECP2 protein will never exceed endogenous levels.
PB  - Oregon Health and Science University
PY  - 2023-09-13
T1  - Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of rett syndrome
TI  - Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of rett syndrome
UR  - https://digitalcollections.ohsu.edu/record/41889/files/ResearchWeek.2023.Yung.John.pdf
Y1  - 2023-09-13
ER  -