TY - GEN N2 - The blood microenvironment is a dynamic system consisting of a diverse range of cells and plasma proteins that function together to maintain homeostasis. In my dissertation, I explored the intricate interplay amongst the different components of the blood microenvironment (e.g. endothelial cells, platelets, and coagulation factors) in studies ranging from in vitro experiments, to in vivo studies with nonhuman primates (NHPs), and clinical studies. My objective was to leverage knowledge of complex blood microenvironment interactions to develop tools targeting the intracellular and extracellular pathways that contribute to the manifestation of vascular diseases and responses to vascular devices. DO - 10.6083/bpxhc41891 DO - doi AB - The blood microenvironment is a dynamic system consisting of a diverse range of cells and plasma proteins that function together to maintain homeostasis. In my dissertation, I explored the intricate interplay amongst the different components of the blood microenvironment (e.g. endothelial cells, platelets, and coagulation factors) in studies ranging from in vitro experiments, to in vivo studies with nonhuman primates (NHPs), and clinical studies. My objective was to leverage knowledge of complex blood microenvironment interactions to develop tools targeting the intracellular and extracellular pathways that contribute to the manifestation of vascular diseases and responses to vascular devices. AD - Oregon Health and Science University T1 - Blood microenvironment of vascular diseases and devices ED - McCarty, Owen ED - Advisor DA - 2023-09-13 AU - Kohs, Tia C.L. L1 - https://digitalcollections.ohsu.edu/record/41891/files/Kohs.Tia.2023.pdf PB - Oregon Health and Science University LA - eng PY - 2023-09-13 ID - 41891 L4 - https://digitalcollections.ohsu.edu/record/41891/files/Kohs.Tia.2023.pdf KW - Blood Coagulation Factors KW - Endothelial Cells KW - Blood Platelets KW - Thromboinflammation KW - Atherosclerosis KW - Multiple Sclerosis KW - blood microenvironment TI - Blood microenvironment of vascular diseases and devices Y1 - 2023-09-13 L2 - https://digitalcollections.ohsu.edu/record/41891/files/Kohs.Tia.2023.pdf LK - https://digitalcollections.ohsu.edu/record/41891/files/Kohs.Tia.2023.pdf UR - https://digitalcollections.ohsu.edu/record/41891/files/Kohs.Tia.2023.pdf ER -