000041891 001__ 41891
000041891 005__ 20240124114339.0
000041891 0247_ $$2doi$$a10.6083/bpxhc41891
000041891 037__ $$aETD
000041891 041__ $$aeng
000041891 245__ $$aBlood microenvironment of vascular diseases and devices
000041891 260__ $$bOregon Health and Science University
000041891 269__ $$a2023-09-13
000041891 336__ $$aDissertation
000041891 502__ $$bPh.D.
000041891 502__ $$gBiomedical Engineering
000041891 520__ $$aThe blood microenvironment is a dynamic system consisting of a diverse range of cells and plasma proteins that function together to maintain homeostasis. In my dissertation, I explored the intricate interplay amongst the different components of the blood microenvironment (e.g. endothelial cells, platelets, and coagulation factors) in studies ranging from in vitro experiments, to in vivo studies with nonhuman primates (NHPs), and clinical studies. My objective was to leverage knowledge of complex blood microenvironment interactions to develop tools targeting the intracellular and extracellular pathways that contribute to the manifestation of vascular diseases and responses to vascular devices.
000041891 540__ $$fCC BY-ND
000041891 542__ $$fIn copyright - single owner
000041891 650__ $$aBlood Coagulation Factors$$015654
000041891 650__ $$aEndothelial Cells$$035222
000041891 650__ $$aBlood Platelets$$015667
000041891 650__ $$aThromboinflammation$$013757
000041891 650__ $$aAtherosclerosis$$036329
000041891 650__ $$aMultiple Sclerosis$$022506
000041891 6531_ $$ablood microenvironment
000041891 691__ $$aSchool of Medicine$$041369
000041891 692__ $$aDepartment of Biomedical Engineering$$041397
000041891 7001_ $$aKohs, Tia C.L.$$uOregon Health and Science University$$041354
000041891 7201_ $$aMcCarty, Owen$$uOregon Health and Science University$$041354$$eAdvisor$$7Personal
000041891 8564_ $$9c86d62b7-8c5c-4179-a722-47921b50d4f5$$s6174818$$uhttps://digitalcollections.ohsu.edu/record/41891/files/Kohs.Tia.2023.pdf
000041891 909CO $$ooai:digitalcollections.ohsu.edu:41891$$pstudent-work
000041891 980__ $$aTheses and Dissertations
000041891 981__ $$aPublished$$b2023-09-13