@article{ETD,
      school = {Ph.D.},
      author = {Rao, Prashant A.},
      url = {http://digitalcollections.ohsu.edu/record/41950},
      title = {From brain tissue to structure: the architecture of  α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid  receptors from two distinct brain regions},
      publisher = {Oregon Health and Science University},
      abstract = {Throughout the central nervous system (CNS), a family of  ligand-gated ion channels known as  α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid  receptors (AMPARs) translate chemical signals to electrical  impulses. While structural mechanisms of receptor gating  and kinetics have been proposed through decades of  recombinant investigations, these studies are limited to  the use of engineered receptor/auxiliary protein complexes,  which have difficulty replicating the in vivo assembly and  architecture of AMPARs. This absence of structural  information prevents not only a bona fide understanding of  these receptor complexes, but also an accurate blueprint  from which to study their kinetics and physiology.  Collectively, this dissertation defines an in vivo  structural landscape of AMPARs with region-specificity.},
      number = {ETD},
      doi = {https://doi.org/10.6083/bpxhc41950},
      recid = {41950},
      address = {2023-09-21},
}