TY  - GEN
N2  - Throughout the central nervous system (CNS), a family of ligand-gated ion channels known as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) translate chemical signals to electrical impulses. While structural mechanisms of receptor gating and kinetics have been proposed through decades of recombinant investigations, these studies are limited to the use of engineered receptor/auxiliary protein complexes, which have difficulty replicating the in vivo assembly and architecture of AMPARs. This absence of structural information prevents not only a bona fide understanding of these receptor complexes, but also an accurate blueprint from which to study their kinetics and physiology. Collectively, this dissertation defines an in vivo structural landscape of AMPARs with region-specificity.
DO  - 10.6083/bpxhc41950
DO  - doi
AB  - Throughout the central nervous system (CNS), a family of ligand-gated ion channels known as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) translate chemical signals to electrical impulses. While structural mechanisms of receptor gating and kinetics have been proposed through decades of recombinant investigations, these studies are limited to the use of engineered receptor/auxiliary protein complexes, which have difficulty replicating the in vivo assembly and architecture of AMPARs. This absence of structural information prevents not only a bona fide understanding of these receptor complexes, but also an accurate blueprint from which to study their kinetics and physiology. Collectively, this dissertation defines an in vivo structural landscape of AMPARs with region-specificity.
T1  - From brain tissue to structure: the architecture of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors from two distinct brain regions
ED  - Gouaux, Eric
ED  - Advisor
DA  - 2023-09-21
AU  - Rao, Prashant A.
L1  - https://digitalcollections.ohsu.edu/record/41950/files/Rao.Prashant.2023.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-09-21
ID  - 41950
L4  - https://digitalcollections.ohsu.edu/record/41950/files/Rao.Prashant.2023.pdf
KW  - Neurosciences
KW  - Receptors, Glutamate
KW  - Biochemistry
KW  - cryo-em
KW  - protein complexes
KW  - structural biology
TI  - From brain tissue to structure: the architecture of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors from two distinct brain regions
Y1  - 2023-09-21
L2  - https://digitalcollections.ohsu.edu/record/41950/files/Rao.Prashant.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/41950/files/Rao.Prashant.2023.pdf
UR  - https://digitalcollections.ohsu.edu/record/41950/files/Rao.Prashant.2023.pdf
ER  -