000041950 001__ 41950
000041950 005__ 20240124114340.0
000041950 0247_ $$2doi$$a10.6083/bpxhc41950
000041950 037__ $$aETD
000041950 041__ $$aeng
000041950 245__ $$aFrom brain tissue to structure: the architecture of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors from two distinct brain regions
000041950 260__ $$bOregon Health and Science University
000041950 269__ $$a2023-09-21
000041950 336__ $$aDissertation
000041950 502__ $$bPh.D.
000041950 502__ $$gNeuroscience
000041950 520__ $$aThroughout the central nervous system (CNS), a family of ligand-gated ion channels known as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) translate chemical signals to electrical impulses. While structural mechanisms of receptor gating and kinetics have been proposed through decades of recombinant investigations, these studies are limited to the use of engineered receptor/auxiliary protein complexes, which have difficulty replicating the in vivo assembly and architecture of AMPARs. This absence of structural information prevents not only a bona fide understanding of these receptor complexes, but also an accurate blueprint from which to study their kinetics and physiology. Collectively, this dissertation defines an in vivo structural landscape of AMPARs with region-specificity.
000041950 540__ $$fCC BY
000041950 542__ $$fIn copyright - single owner
000041950 650__ $$aNeurosciences$$022870
000041950 650__ $$aReceptors, Glutamate$$029996
000041950 650__ $$aBiochemistry$$015549
000041950 6531_ $$acryo-em
000041950 6531_ $$aprotein complexes
000041950 6531_ $$astructural biology
000041950 691__ $$aSchool of Medicine$$041369
000041950 692__ $$aVollum Institute$$041509
000041950 7001_ $$aRao, Prashant A.
000041950 7201_ $$aGouaux, Eric$$uOregon Health and Science University$$041354$$10000-0002-8549-2360$$eAdvisor$$7Personal
000041950 8564_ $$95c76df08-b3a1-48f5-9836-afa4235ea53b$$s30812428$$uhttps://digitalcollections.ohsu.edu/record/41950/files/Rao.Prashant.2023.pdf
000041950 909CO $$ooai:digitalcollections.ohsu.edu:41950$$pstudent-work
000041950 980__ $$aTheses and Dissertations
000041950 981__ $$aPublished$$b2023-09-21