TY  - GEN
AB  - Just over 20% of American adults suffer from chronic pain, making chronic pain one of the most significant health concerns affecting individuals in the United States. For many chronic pain disorders, the prevalence is higher amongst women.  In order to elucidate the actions underlying the development and treatment of chronic pain, as well as associated behaviors, animal models are necessary. However, as we have not produced a novel treatment for chronic pain in some time, many researchers are calling for better behavioral measures, citing a lack of translational validity in our measures as the reason for this slow progress. Efforts to design novel behavioral assays increased, but this movement has not yet had its intended impact, and whether it ever will is questionable. This is because other major issues exist in the field that are being ignored: insufficient understanding of the patient population and individualized medicine, the omittance of negative data that would inform other researchers of what not to do, a lack of personal accountability amongst researchers, and an inappropriate perception of the goals of animal research are some of these issues.
AU  - Morgan, Andrea D.
DA  - 2023-09-21
DO  - 10.6083/bpxhc41955
DO  - doi
ED  - Heinricher, Mary
ED  - Advisor
ID  - 41955
KW  - Neurosciences
KW  - Chronic Pain
KW  - Pain
KW  - Behavior
KW  - animal subjects
KW  - confounds in research
L1  - https://digitalcollections.ohsu.edu/record/41955/files/Morgan.Andrea.2023.pdf
L2  - https://digitalcollections.ohsu.edu/record/41955/files/Morgan.Andrea.2023.pdf
L4  - https://digitalcollections.ohsu.edu/record/41955/files/Morgan.Andrea.2023.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/41955/files/Morgan.Andrea.2023.pdf
N2  - Just over 20% of American adults suffer from chronic pain, making chronic pain one of the most significant health concerns affecting individuals in the United States. For many chronic pain disorders, the prevalence is higher amongst women.  In order to elucidate the actions underlying the development and treatment of chronic pain, as well as associated behaviors, animal models are necessary. However, as we have not produced a novel treatment for chronic pain in some time, many researchers are calling for better behavioral measures, citing a lack of translational validity in our measures as the reason for this slow progress. Efforts to design novel behavioral assays increased, but this movement has not yet had its intended impact, and whether it ever will is questionable. This is because other major issues exist in the field that are being ignored: insufficient understanding of the patient population and individualized medicine, the omittance of negative data that would inform other researchers of what not to do, a lack of personal accountability amongst researchers, and an inappropriate perception of the goals of animal research are some of these issues.
PB  - Oregon Health and Science University
PY  - 2023-09-21
T1  - Pain-related behavior and potential confounds in the  study of laboratory animals
TI  - Pain-related behavior and potential confounds in the  study of laboratory animals
UR  - https://digitalcollections.ohsu.edu/record/41955/files/Morgan.Andrea.2023.pdf
Y1  - 2023-09-21
ER  -