000041955 001__ 41955 000041955 005__ 20240124114340.0 000041955 0247_ $$2doi$$a10.6083/bpxhc41955 000041955 037__ $$aETD 000041955 041__ $$aeng 000041955 245__ $$aPain-related behavior and potential confounds in the study of laboratory animals 000041955 260__ $$bOregon Health and Science University 000041955 269__ $$a2023-09-21 000041955 336__ $$aDissertation 000041955 502__ $$bPh.D. 000041955 502__ $$gBehavioral & Systems Neuroscience 000041955 520__ $$aJust over 20% of American adults suffer from chronic pain, making chronic pain one of the most significant health concerns affecting individuals in the United States. For many chronic pain disorders, the prevalence is higher amongst women. In order to elucidate the actions underlying the development and treatment of chronic pain, as well as associated behaviors, animal models are necessary. However, as we have not produced a novel treatment for chronic pain in some time, many researchers are calling for better behavioral measures, citing a lack of translational validity in our measures as the reason for this slow progress. Efforts to design novel behavioral assays increased, but this movement has not yet had its intended impact, and whether it ever will is questionable. This is because other major issues exist in the field that are being ignored: insufficient understanding of the patient population and individualized medicine, the omittance of negative data that would inform other researchers of what not to do, a lack of personal accountability amongst researchers, and an inappropriate perception of the goals of animal research are some of these issues. 000041955 540__ $$fCC BY 000041955 542__ $$fIn copyright - single owner 000041955 650__ $$aNeurosciences$$022870 000041955 650__ $$aChronic Pain$$039552 000041955 650__ $$aPain$$023476 000041955 650__ $$aBehavior$$015411 000041955 6531_ $$aanimal subjects 000041955 6531_ $$aconfounds in research 000041955 691__ $$aSchool of Medicine$$041369 000041955 692__ $$aDepartment of Behavioral Neuroscience$$041394 000041955 7001_ $$aMorgan, Andrea D. 000041955 7201_ $$aHeinricher, Mary$$uOregon Health and Science University$$041354$$eAdvisor$$7Personal 000041955 8564_ $$9057f0c00-2ac1-4d0e-b8ca-1d4922ebaace$$s862130$$uhttps://digitalcollections.ohsu.edu/record/41955/files/Morgan.Andrea.2023.pdf 000041955 909CO $$ooai:digitalcollections.ohsu.edu:41955$$pstudent-work 000041955 980__ $$aTheses and Dissertations 000041955 981__ $$aPublished$$b2023-09-21