TY  - GEN
N2  - Structural biology is ultimately the study of particular domains and residues, but this knowledge most interesting and useful in the con-text of physiological processes. As such, it can be difficult to order the chapters of an introduction. Placing the structure before the function grounds discussion of mutations and disease, but leaves the structure unmoored from biomedical relevance. Conversely, placing function first leaves the reader without a clear understanding of which do-mains are important for which reasons, which is vital for a focused discussion of the protein. To dodge the question of which is the cart and which is the course, I present here an exceedingly brief (and less heavily cited) discussion of ENaC structure and function.
DO  - 10.6083/bpxhc42004
DO  - doi
AB  - Structural biology is ultimately the study of particular domains and residues, but this knowledge most interesting and useful in the con-text of physiological processes. As such, it can be difficult to order the chapters of an introduction. Placing the structure before the function grounds discussion of mutations and disease, but leaves the structure unmoored from biomedical relevance. Conversely, placing function first leaves the reader without a clear understanding of which do-mains are important for which reasons, which is vital for a focused discussion of the protein. To dodge the question of which is the cart and which is the course, I present here an exceedingly brief (and less heavily cited) discussion of ENaC structure and function.
T1  - ENaC isn't ASIC: a study of various activating mutations and conditions of the epithelial sodium channel
ED  - Baconguis,  Isabelle
ED  - Advisor
DA  - 2023-09-21
AU  - Posert, Richard
L1  - https://digitalcollections.ohsu.edu/record/42004/files/Posert.Rich.2023.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-09-21
ID  - 42004
L4  - https://digitalcollections.ohsu.edu/record/42004/files/Posert.Rich.2023.pdf
KW  - Ion Channels
KW  - Cryoelectron Microscopy
KW  - Blood Pressure
KW  - structural biochemistry
KW  - size exclusion chromatography
TI  - ENaC isn't ASIC: a study of various activating mutations and conditions of the epithelial sodium channel
Y1  - 2023-09-21
L2  - https://digitalcollections.ohsu.edu/record/42004/files/Posert.Rich.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/42004/files/Posert.Rich.2023.pdf
UR  - https://digitalcollections.ohsu.edu/record/42004/files/Posert.Rich.2023.pdf
ER  -