000042005 001__ 42005 000042005 005__ 20240124114340.0 000042005 0247_ $$2doi$$a10.6083/bpxhc42005 000042005 037__ $$aETD 000042005 041__ $$aeng 000042005 245__ $$aImproved modeling of biochemical reaction networks: applications towards transporter mechanism discovery 000042005 260__ $$bOregon Health and Science University 000042005 269__ $$a2023-09-21 000042005 336__ $$aDissertation 000042005 502__ $$bPh.D. 000042005 502__ $$gBiomedical Engineering 000042005 520__ $$aBiochemical reaction networks, mathematical models that describe the dynamic interrelationships between biochemical species, facilitate studying complex biological processes such as cell signaling, metabolism, and enzyme kinetics. This work focuses on secondary active membrane transporter proteins which selectively move nutrients across the cell membrane using the energy stored in electrochemical gradients. 000042005 540__ $$fCC BY 000042005 542__ $$fIn copyright - single owner 000042005 650__ $$aSystems Biology$$036214 000042005 6531_ $$atransporters 000042005 6531_ $$achemical reaction networks 000042005 6531_ $$abayesian inference 000042005 6531_ $$acomputational statistics 000042005 6531_ $$adynamic systems 000042005 691__ $$aSchool of Medicine$$041369 000042005 692__ $$aDepartment of Biomedical Engineering$$041397 000042005 7001_ $$aGeorge, August D. 000042005 7201_ $$aZuckerman, Daniel$$uOregon Health and Science University$$041354$$eAdvisor$$7Personal 000042005 8564_ $$95537002b-c6f9-49bf-97f1-771cd63ec473$$s10971667$$uhttps://digitalcollections.ohsu.edu/record/42005/files/George.August.2023.pdf 000042005 909CO $$ooai:digitalcollections.ohsu.edu:42005$$pstudent-work 000042005 980__ $$aTheses and Dissertations 000042005 981__ $$aPublished$$b2023-09-21