000042312 001__ 42312
000042312 005__ 20240124114340.0
000042312 0247_ $$2doi$$a10.6083/bpxhc42312
000042312 037__ $$aETD
000042312 041__ $$aeng
000042312 245__ $$aDynamics of antigen processing and presentation in the context of cancer
000042312 260__ $$bOregon Health and Science University
000042312 269__ $$a2023-11-07
000042312 336__ $$aDissertation
000042312 502__ $$bPh.D.
000042312 502__ $$gBiomedical Engineering
000042312 520__ $$aImmunotherapeutic approaches, aimed at modulating the immune system’s response to cancer and other diseases, have garnered increasing attention over the past decade. For some cancers such as melanoma, non-small cell lung cancer, and B-cell lymphomas, immunotherapy options have been transformative and some patients respond even in the most aggressive and refractory cases. Despite the optimism surrounding various immune-based approaches, many patients still don’t respond to treatment and the reasons why are poorly understood. The disparity in responses across patients and cancer types has highlighted a dire need for a better mechanistic understanding of the factors involved in therapeutic response to immunotherapies; supported by tools that help define which patients will benefit from these novel treatment options. While a variety of approaches exist in the immunotherapy space, some with systemic affects and others focused on specific immune targets, all approaches rely heavily on the adaptive immune system and response to class I antigens.
000042312 540__ $$fCC BY
000042312 542__ $$fPublic domain
000042312 650__ $$aAntigen Presentation$$030374
000042312 650__ $$aImmunotherapy$$020724
000042312 650__ $$aProstatic Neoplasms$$024731
000042312 6531_ $$aantigen processing
000042312 6531_ $$aprostate cancer
000042312 6531_ $$apepsickle
000042312 691__ $$aSchool of Medicine$$041369
000042312 692__ $$aDepartment of Biomedical Engineering$$041397
000042312 7001_ $$aWeeder, Benjamin
000042312 8564_ $$94d6ed4be-1552-4215-ae46-bf8121537d25$$s6347885$$uhttps://digitalcollections.ohsu.edu/record/42312/files/Weeder.Benjamin.2023.pdf
000042312 909CO $$ooai:digitalcollections.ohsu.edu:42312$$pstudent-work
000042312 980__ $$aTheses and Dissertations
000042312 981__ $$aPublished$$b2023-11-07