TY  - GEN
AB  - Schizophrenia (SCZ) is a complex neuropsychiatric disorder thought to arise from an interplay of environmental and genetic risk factors. The presentation of disease symptomology is heterogenous due to the polygenicity of the disorder. The standard antipsychotic drug treatments lack target specificity, have severe side effects, and do not alleviate the most disabling negative and cognitive symptoms. This may be due to a lack of understanding SCZ pathophysiology. Genome-wide association studies (GWAS) identified candidate alleles, largely involved in regulating synaptic function, which confer increased risk for SCZ. The host gene MIR137, contains the primary transcript of microRNA137 (miR137), is strongly implicated in SCZ risk and is associated with more severe psychiatric symptoms. MiR137 regulates tens to hundreds of target transcripts involved in neurodevelopment and synaptic function. Since SCZ is a neurodevelopmental disorder characterized by synaptic dysfunction, miR137 represents an interesting target to modulate protein expression in the prefrontal cortex (PFC), one of the most impacted brain regions. Thus, to improve treatments for people with SCZ, this dissertation investigated the ability of nanoparticles to deliver nucleic acid cargo to the PFC to alter synaptic protein expression. 
AD  - Oregon Health and Science University
AU  - Palumbo, Michelle
DA  - 2023-12-05
DO  - 10.6083/bpxhc42372
DO  - doi
ED  - Janowsky, Aaron
ED  - Abbas, Atheir
ED  - Marks, Dan
ED  - Miranda, Rajesh
ED  - Sahay, Gaurav
ED  - Advisor
ED  - Co-Mentor
ED  - Committee chair
ED  - Committee member
ED  - Collaborator
ID  - 42372
KW  - Nanoparticle Drug Delivery System
KW  - Schizophrenia
KW  - MicroRNAs
KW  - brain delivery
KW  - glutamate networks
KW  - lipid nanoparticle
KW  - synaptic proteins
L1  - https://digitalcollections.ohsu.edu/record/42372/files/MolTher%20Copywrite%20Permission%20Email.pdf
L1  - https://digitalcollections.ohsu.edu/record/42372/files/Palumbo.Michelle.2023.pdf
L2  - https://digitalcollections.ohsu.edu/record/42372/files/MolTher%20Copywrite%20Permission%20Email.pdf
L2  - https://digitalcollections.ohsu.edu/record/42372/files/Palumbo.Michelle.2023.pdf
L4  - https://digitalcollections.ohsu.edu/record/42372/files/MolTher%20Copywrite%20Permission%20Email.pdf
L4  - https://digitalcollections.ohsu.edu/record/42372/files/Palumbo.Michelle.2023.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/42372/files/MolTher%20Copywrite%20Permission%20Email.pdf
LK  - https://digitalcollections.ohsu.edu/record/42372/files/Palumbo.Michelle.2023.pdf
N2  - Schizophrenia (SCZ) is a complex neuropsychiatric disorder thought to arise from an interplay of environmental and genetic risk factors. The presentation of disease symptomology is heterogenous due to the polygenicity of the disorder. The standard antipsychotic drug treatments lack target specificity, have severe side effects, and do not alleviate the most disabling negative and cognitive symptoms. This may be due to a lack of understanding SCZ pathophysiology. Genome-wide association studies (GWAS) identified candidate alleles, largely involved in regulating synaptic function, which confer increased risk for SCZ. The host gene MIR137, contains the primary transcript of microRNA137 (miR137), is strongly implicated in SCZ risk and is associated with more severe psychiatric symptoms. MiR137 regulates tens to hundreds of target transcripts involved in neurodevelopment and synaptic function. Since SCZ is a neurodevelopmental disorder characterized by synaptic dysfunction, miR137 represents an interesting target to modulate protein expression in the prefrontal cortex (PFC), one of the most impacted brain regions. Thus, to improve treatments for people with SCZ, this dissertation investigated the ability of nanoparticles to deliver nucleic acid cargo to the PFC to alter synaptic protein expression. 
PB  - Oregon Health and Science University
PY  - 2023-12-05
T1  - Delivering schizophrenia-associated MicroRNA137 to the prefrontal cortex by lipid nanoparticles
TI  - Delivering schizophrenia-associated MicroRNA137 to the prefrontal cortex by lipid nanoparticles
UR  - https://digitalcollections.ohsu.edu/record/42372/files/MolTher%20Copywrite%20Permission%20Email.pdf
UR  - https://digitalcollections.ohsu.edu/record/42372/files/Palumbo.Michelle.2023.pdf
Y1  - 2023-12-05
ER  -