TY  - GEN
AB  - While it is becoming more appreciated that non-hematopoietic cells within barrier tissues participate in and modulate the host immune response, their roles are still incompletely understood. Understanding how cell subsets within the tissue microenvironment regulate the immune response will provide more knowledge in designing tissue specific vaccination strategies as well as uncovering how inflammatory processes are dysregulated during chronic disease. Herein, I describe my thesis work where I investigate how two types of non-hematopoietic cells, lymphatic endothelial cells and tuft cells, influence downstream inflammatory responses in skin and small intestine. I demonstrate that lymphatic vessels, in response to viral cutaneous infection, remodel their cellular junctions.
AD  - Oregon Health and Science University
AU  - Churchill, Madeline
DA  - 2023-12-08
ID  - 42376
KW  - lymphatic endothelial cells
KW  - inflammatory responses
KW  - non-hematopoeitic cells
KW  - tuft cells
L1  - https://digitalcollections.ohsu.edu/record/42376/files/Churchill.Madeline.2023.pdf
L2  - https://digitalcollections.ohsu.edu/record/42376/files/Churchill.Madeline.2023.pdf
L4  - https://digitalcollections.ohsu.edu/record/42376/files/Churchill.Madeline.2023.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/42376/files/Churchill.Madeline.2023.pdf
N2  - While it is becoming more appreciated that non-hematopoietic cells within barrier tissues participate in and modulate the host immune response, their roles are still incompletely understood. Understanding how cell subsets within the tissue microenvironment regulate the immune response will provide more knowledge in designing tissue specific vaccination strategies as well as uncovering how inflammatory processes are dysregulated during chronic disease. Herein, I describe my thesis work where I investigate how two types of non-hematopoietic cells, lymphatic endothelial cells and tuft cells, influence downstream inflammatory responses in skin and small intestine. I demonstrate that lymphatic vessels, in response to viral cutaneous infection, remodel their cellular junctions.
PB  - Oregon Health and Science University
PY  - 2023-12-08
T1  - A tale of two tissues: non-hematopoietic cells control tissue-specific host inflammatory responses within barrier tissues.
TI  - A tale of two tissues: non-hematopoietic cells control tissue-specific host inflammatory responses within barrier tissues.
UR  - https://digitalcollections.ohsu.edu/record/42376/files/Churchill.Madeline.2023.pdf
Y1  - 2023-12-08
ER  -