000042376 001__ 42376
000042376 005__ 20240124114341.0
000042376 037__ $$aETD
000042376 041__ $$aeng
000042376 245__ $$aA tale of two tissues: non-hematopoietic cells control tissue-specific host inflammatory responses within barrier tissues.
000042376 260__ $$bOregon Health and Science University
000042376 269__ $$a2023-12-08
000042376 336__ $$aDissertation
000042376 502__ $$bPh.D.
000042376 502__ $$gMolecular Microbiology & Immunology
000042376 520__ $$aWhile it is becoming more appreciated that non-hematopoietic cells within barrier tissues participate in and modulate the host immune response, their roles are still incompletely understood. Understanding how cell subsets within the tissue microenvironment regulate the immune response will provide more knowledge in designing tissue specific vaccination strategies as well as uncovering how inflammatory processes are dysregulated during chronic disease. Herein, I describe my thesis work where I investigate how two types of non-hematopoietic cells, lymphatic endothelial cells and tuft cells, influence downstream inflammatory responses in skin and small intestine. I demonstrate that lymphatic vessels, in response to viral cutaneous infection, remodel their cellular junctions.
000042376 540__ $$fNo License
000042376 542__ $$fPublic domain
000042376 6531_ $$alymphatic endothelial cells
000042376 6531_ $$ainflammatory responses
000042376 6531_ $$anon-hematopoeitic cells
000042376 6531_ $$atuft cells
000042376 691__ $$aSchool of Medicine$$041369
000042376 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000042376 7001_ $$aChurchill, Madeline$$uOregon Health and Science University$$041354
000042376 7201_ $$7Personal
000042376 8564_ $$9ef0d5231-c1e8-4fe2-a824-f7beda524fd9$$s18921990$$uhttps://digitalcollections.ohsu.edu/record/42376/files/Churchill.Madeline.2023.pdf
000042376 909CO $$ooai:digitalcollections.ohsu.edu:42376$$pstudent-work
000042376 980__ $$aTheses and Dissertations
000042376 981__ $$aPublished$$b2023-12-11