TY  - GEN
N2  - Central nervous system demyelination occurs in numerous conditions, including multiple sclerosis (MS). Remyelination in acute lesions involves the recruitment and maturation of oligodendrocyte progenitor cells (OPCs). However, remyelination fails in chronic lesions in part due to the failure of OPCs to mature into myelinating oligodendrocytes (OLs). Digestion products of the glycosaminoglycan hyaluronan (HA), generated by hyaluronidase activity within demyelinating lesions, are among the signals that block OPC maturation and remyelination. However, the identity and source of this hyaluronidase activity is unknown.
DO  - 10.6083/bpxhc42378
DO  - doi
AB  - Central nervous system demyelination occurs in numerous conditions, including multiple sclerosis (MS). Remyelination in acute lesions involves the recruitment and maturation of oligodendrocyte progenitor cells (OPCs). However, remyelination fails in chronic lesions in part due to the failure of OPCs to mature into myelinating oligodendrocytes (OLs). Digestion products of the glycosaminoglycan hyaluronan (HA), generated by hyaluronidase activity within demyelinating lesions, are among the signals that block OPC maturation and remyelination. However, the identity and source of this hyaluronidase activity is unknown.
AD  - Oregon Health and Science University
T1  - The hyaluronidase cell migration inducing and hyaluronan binding protein is elevated during inflammatory demyelination and inhibits remyelination
ED  - Sherman, Lawrence
ED  - Copenhaver, Philip
ED  - Barnes, Anthony
ED  - Back, Stephen
ED  - Emery, Ben
ED  - Mentor
ED  - Committee chair
ED  - Committee member
ED  - Committee member
ED  - Committee member
DA  - 2023-09-01
AU  - Peters, Alec
L1  - https://digitalcollections.ohsu.edu/record/42378/files/Peters.Alec.2023.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-09-01
ID  - 42378
L4  - https://digitalcollections.ohsu.edu/record/42378/files/Peters.Alec.2023.pdf
KW  - Multiple Sclerosis
KW  - Hyaluronic Acid
KW  - Extracellular Matrix
KW  - Myelin Sheath
KW  - Oligodendroglia
KW  - oligodendrocyte
TI  - The hyaluronidase cell migration inducing and hyaluronan binding protein is elevated during inflammatory demyelination and inhibits remyelination
Y1  - 2023-09-01
L2  - https://digitalcollections.ohsu.edu/record/42378/files/Peters.Alec.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/42378/files/Peters.Alec.2023.pdf
UR  - https://digitalcollections.ohsu.edu/record/42378/files/Peters.Alec.2023.pdf
ER  -