000042378 001__ 42378
000042378 005__ 20240124114341.0
000042378 0247_ $$2doi$$a10.6083/bpxhc42378
000042378 037__ $$aETD
000042378 041__ $$aeng
000042378 245__ $$aThe hyaluronidase cell migration inducing and hyaluronan binding protein is elevated during inflammatory demyelination and inhibits remyelination
000042378 260__ $$bOregon Health and Science University
000042378 269__ $$a2023-09-01
000042378 336__ $$aDissertation
000042378 502__ $$bPh.D.
000042378 502__ $$gCell & Developmental Biology
000042378 520__ $$aCentral nervous system demyelination occurs in numerous conditions, including multiple sclerosis (MS). Remyelination in acute lesions involves the recruitment and maturation of oligodendrocyte progenitor cells (OPCs). However, remyelination fails in chronic lesions in part due to the failure of OPCs to mature into myelinating oligodendrocytes (OLs). Digestion products of the glycosaminoglycan hyaluronan (HA), generated by hyaluronidase activity within demyelinating lesions, are among the signals that block OPC maturation and remyelination. However, the identity and source of this hyaluronidase activity is unknown.
000042378 536__ $$oNIH$$cT32AG055378
000042378 536__ $$oNIH$$cT32GM071338
000042378 536__ $$oNMSS$$cRG-1702-27047
000042378 536__ $$oCDMRP MS$$cMS160144
000042378 540__ $$fCC BY-NC-SA
000042378 542__ $$fIn copyright - single owner
000042378 650__ $$aMultiple Sclerosis$$022506
000042378 650__ $$aHyaluronic Acid$$020392
000042378 650__ $$aExtracellular Matrix$$018796
000042378 650__ $$aMyelin Sheath$$022587
000042378 650__ $$aOligodendroglia$$023183
000042378 6531_ $$aoligodendrocyte
000042378 691__ $$aSchool of Medicine$$041369
000042378 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000042378 7001_ $$aPeters, Alec$$uOregon Health and Science University$$041354$$10000-0003-1844-2870
000042378 7201_ $$aSherman, Lawrence$$uOregon Health and Science University$$041354$$eMentor$$7Personal
000042378 7201_ $$aCopenhaver, Philip$$uOregon Health and Science University$$041354$$eCommittee chair$$7Personal
000042378 7201_ $$aBarnes, Anthony$$uOregon Health and Science University$$041354$$eCommittee member$$7Personal
000042378 7201_ $$aBack, Stephen$$uOregon Health and Science University$$041354$$eCommittee member$$7Personal
000042378 7201_ $$aEmery, Ben$$uOregon Health and Science University$$041354$$eCommittee member$$7Personal
000042378 8564_ $$9da5c3ea5-7b7f-4d9e-8d31-5cfecfac59e0$$s4082391$$uhttps://digitalcollections.ohsu.edu/record/42378/files/Peters.Alec.2023.pdf
000042378 909CO $$ooai:digitalcollections.ohsu.edu:42378$$pstudent-work
000042378 980__ $$aTheses and Dissertations
000042378 981__ $$aPublished$$b2023-12-13