TY  - GEN
N2  - The etiology of adolescent internalizing psychopathology (e.g., anxiety and depression) is not yet fully understood, and for that reason it has been difficult to identify reliable biomarkers that predict symptoms. This dissertation work establishes both neurobiological and psychosocial predictors of internalizing psychopathology in adolescence by leveraging several advanced statistical and machine learning techniques in a large and demographically diverse sample. Aim 1 of this project uses resting-state fMRI data to identify a profile of functional connectivity (a 'polyneuro risk score') that is associated with internalizing symptoms, whereas Aim 2 focuses on combining psychosocial, environmental, and behavioral variables to predict symptoms. The findings from these two analyses highlight the utility of multivariate modeling strategies for prediction and also help to reconcile decades of prior literature examining key factors related to the emergence of anxiety and depression in youth.
DO  - 10.6083/bpxhc42387
DO  - doi
AB  - The etiology of adolescent internalizing psychopathology (e.g., anxiety and depression) is not yet fully understood, and for that reason it has been difficult to identify reliable biomarkers that predict symptoms. This dissertation work establishes both neurobiological and psychosocial predictors of internalizing psychopathology in adolescence by leveraging several advanced statistical and machine learning techniques in a large and demographically diverse sample. Aim 1 of this project uses resting-state fMRI data to identify a profile of functional connectivity (a 'polyneuro risk score') that is associated with internalizing symptoms, whereas Aim 2 focuses on combining psychosocial, environmental, and behavioral variables to predict symptoms. The findings from these two analyses highlight the utility of multivariate modeling strategies for prediction and also help to reconcile decades of prior literature examining key factors related to the emergence of anxiety and depression in youth.
AD  - Oregon Health and Science University
T1  - Characterizing neural and psychosocial predictors of internalizing psychopathology in early adolescence
ED  - Nigg, Joel
ED  - Graham, Alice
ED  - Mackiewicz Seghete, Kristen
ED  - Mitchell, Suzanne
ED  - Nagel, Bonnie
ED  - Miranda-Dominguez, Oscar
ED  - Byington, Nora
ED  - Espinoza, Abigail
ED  - Lopez Flores, Arturo
ED  - Harman, Gareth
ED  - Fair, Damien
ED  - Committee chair
ED  - Committee member
ED  - Committee member
ED  - Committee member
ED  - Mentor
ED  - Collaborator
ED  - Collaborator
ED  - Collaborator
ED  - Collaborator
ED  - Collaborator
ED  - Collaborator
DA  - 2023-12-15
AU  - Kliamovich, Dakota
L1  - https://digitalcollections.ohsu.edu/record/42387/files/Kliamovich.Dakota.2023.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2023-12-15
ID  - 42387
L4  - https://digitalcollections.ohsu.edu/record/42387/files/Kliamovich.Dakota.2023.pdf
KW  - Adolescent Development
KW  - Depression
KW  - Anxiety
KW  - Functional Neuroimaging
KW  - Psychosocial Functioning
KW  - adolescence, internalizing psychopathology, resting-state fmri
TI  - Characterizing neural and psychosocial predictors of internalizing psychopathology in early adolescence
Y1  - 2023-12-15
L2  - https://digitalcollections.ohsu.edu/record/42387/files/Kliamovich.Dakota.2023.pdf
LK  - https://digitalcollections.ohsu.edu/record/42387/files/Kliamovich.Dakota.2023.pdf
UR  - https://digitalcollections.ohsu.edu/record/42387/files/Kliamovich.Dakota.2023.pdf
ER  -