000042682 001__ 42682 000042682 005__ 20240405095434.0 000042682 0247_ $$2doi$$a10.6083/bpxhc42682 000042682 037__ $$aETD 000042682 041__ $$aeng 000042682 245__ $$aDeveloping optically-cleavable targeted (OCT)-ligands: a chemigenetic approach for studying endocannabinoid signaling in pancreatic islets 000042682 260__ $$bOregon Health and Science University 000042682 269__ $$a2024-02-05 000042682 336__ $$aThesis 000042682 502__ $$bPh.D. 000042682 502__ $$gPhysiology & Pharmacology 000042682 520__ $$aMarijuana legalization in the United States, both recreationally or medicinally, has increased its use in adults, yet the full impact of cannabinoid molecules found in marijuana on endogenous signaling pathways is unknown. Cannabinoid signaling has been tied to metabolism and pancreatic islet function, which is responsible for maintaining euglycemia. 000042682 540__ $$fCC BY-NC 000042682 542__ $$fCopyright unknown 000042682 650__ $$aDiabetes Mellitus$$017671 000042682 650__ $$aEndocannabinoids$$040230 000042682 6531_ $$atargeted photopharmacology 000042682 691__ $$aSchool of Medicine$$041369 000042682 692__ $$aDepartment of Chemical Physiology and Biochemistry$$041400 000042682 7001_ $$aTobias, Janelle M.$$uOregon Health and Science University$$041354$$10000-0003-1700-2646 000042682 7201_ $$aFrank, James A.$$uOregon Health and Science University$$041354$$10000-0001-6705-2540$$ePI$$7Personal 000042682 8564_ $$9660890a6-66c4-42d1-a241-801450d93235$$s10137097$$uhttps://digitalcollections.ohsu.edu/record/42682/files/Tobias.Janelle.2024.pdf 000042682 909CO $$ooai:digitalcollections.ohsu.edu:42682$$pstudent-work 000042682 980__ $$aTheses and Dissertations 000042682 981__ $$aPublished$$b2024-02-06