TY - GEN N2 - This thesis describes the role of RI-I modulation in the vascular system. I identify a novel role for RIG-I activation in endothelial function, as well as a role for RIG-I inhibition in endothelial function. Together, I find that homeostatic RIG-I signaling is critical for proper endothelial activity. DO - 10.6083/bpxhc42683 DO - doi AB - This thesis describes the role of RI-I modulation in the vascular system. I identify a novel role for RIG-I activation in endothelial function, as well as a role for RIG-I inhibition in endothelial function. Together, I find that homeostatic RIG-I signaling is critical for proper endothelial activity. AD - Oregon Health and Science University T1 - Retinoic acid inducible gene-I (RIG-I) modulates endothelial cell function ED - Anand, Sudarshan ED - PI DA - 2024-02-07 AU - Baris, Adrian L1 - https://digitalcollections.ohsu.edu/record/42683/files/Baris.Adrian.2024.pdf PB - Oregon Health and Science University LA - eng PY - 2024-02-07 ID - 42683 L4 - https://digitalcollections.ohsu.edu/record/42683/files/Baris.Adrian.2024.pdf KW - Endothelial Cells KW - Vascular Endothelial Growth Factor Receptor-2 KW - Inflammation KW - innate immune system KW - RIG-I KW - angiogenesis TI - Retinoic acid inducible gene-I (RIG-I) modulates endothelial cell function Y1 - 2024-02-07 L2 - https://digitalcollections.ohsu.edu/record/42683/files/Baris.Adrian.2024.pdf LK - https://digitalcollections.ohsu.edu/record/42683/files/Baris.Adrian.2024.pdf UR - https://digitalcollections.ohsu.edu/record/42683/files/Baris.Adrian.2024.pdf ER -