TY  - GEN
N2  - Gene transcription is fundamental in establishing and maintaining cell identity and function. All normal cells are encoded with the same DNA, so transcription is essential for regulating many biological processes, including blood cell formation. Dysregulation of the complex transcriptional mechanisms governing blood cell formation can result in the development of hematologic malignancies, including acute myeloid leukemia (AML). AML is an aggressive blood cancer characterized by the rapid outgrowth of immature blood cells. Despite advances in treatment, AML remains an often fatal disease with a 5-year survival rate of less than 30%. This dissertation aims to uncover mechanisms of transcriptional dysregulation in AML, nominating novel molecular targets that can be used to design more effective treatment strategies.
DO  - 10.6083/bpxhc42697
DO  - doi
AB  - Gene transcription is fundamental in establishing and maintaining cell identity and function. All normal cells are encoded with the same DNA, so transcription is essential for regulating many biological processes, including blood cell formation. Dysregulation of the complex transcriptional mechanisms governing blood cell formation can result in the development of hematologic malignancies, including acute myeloid leukemia (AML). AML is an aggressive blood cancer characterized by the rapid outgrowth of immature blood cells. Despite advances in treatment, AML remains an often fatal disease with a 5-year survival rate of less than 30%. This dissertation aims to uncover mechanisms of transcriptional dysregulation in AML, nominating novel molecular targets that can be used to design more effective treatment strategies.
AD  - Oregon Health and Science University
T1  - Investigating transcriptional dysregulation in acute myeloid leukemia to inform novel therapeutic strategies
DA  - 2024-02-23
AU  - Yashar, William
L1  - https://digitalcollections.ohsu.edu/record/42697/files/William.Yashar.2024.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2024-02-23
ID  - 42697
L4  - https://digitalcollections.ohsu.edu/record/42697/files/William.Yashar.2024.pdf
KW  - Transcription, Genetic
KW  - Leukemia, Myeloid, Acute
KW  - Drug Combinations
KW  - Computational Biology
KW  - Drug Resistance
KW  - Gene Regulatory Networks
KW  - FLT3-ITD
KW  - LSD1 inhibition
KW  - MYC blood super-enhancer
KW  - GoPeaks
KW  - priori
KW  - transcription factor activity
KW  - CUT&Tag
KW  - histone modification
KW  - venetoclax resistance
TI  - Investigating transcriptional dysregulation in acute myeloid leukemia to inform novel therapeutic strategies
Y1  - 2024-02-23
L2  - https://digitalcollections.ohsu.edu/record/42697/files/William.Yashar.2024.pdf
LK  - https://digitalcollections.ohsu.edu/record/42697/files/William.Yashar.2024.pdf
UR  - https://digitalcollections.ohsu.edu/record/42697/files/William.Yashar.2024.pdf
ER  -