000042699 001__ 42699
000042699 005__ 20251005231932.0
000042699 0247_ $$2doi$$a10.6083/bpxhc42699
000042699 037__ $$aETD
000042699 041__ $$aeng
000042699 245__ $$aBloodlines matter: leukemia associated mutation FLT3-ITD disrupts dendritic cell homeostasis and leads to altered T cell phenotypes
000042699 260__ $$bOregon Health and Science University
000042699 269__ $$a2024-02-24
000042699 336__ $$aDissertation
000042699 502__ $$bPh.D.
000042699 502__ $$gMolecular Microbiology & Immunology (sunsetting)
000042699 520__ $$aDendritic cells (DCs) play a crucial role in mediating immune responses to pathogens and tumors, with their development influenced by signaling from the FLT3 receptor tyrosine kinase in bone marrow myeloid progenitors. Recent updates differentiate between conventional DCs (cDCs) and plasmacytoid DCs (pDCs). Activating mutations in FLT3, such as FLT3-ITD, correlate with poor outcomes in acute myeloid leukemia (AML). Distinguishing cDCs from AML cells can be challenging due to their shared lineage.
000042699 540__ $$fCC BY-NC
000042699 542__ $$fIn copyright - single owner
000042699 650__ $$aAntigen-Presenting Cells$$014881
000042699 650__ $$aAllergy and Immunology$$014456
000042699 650__ $$aSingle-Cell Gene Expression Analysis$$013872
000042699 650__ $$aDendritic Cells$$017468
000042699 650__ $$aCytokines$$028964
000042699 6531_ $$aAML
000042699 6531_ $$aSingle Cell
000042699 6531_ $$aCD4 T cell
000042699 6531_ $$aCITE-seq
000042699 6531_ $$aRNAseq
000042699 6531_ $$aTh17
000042699 6531_ $$aCancer
000042699 6531_ $$acDCs
000042699 691__ $$aSchool of Medicine$$041369
000042699 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000042699 7001_ $$uOregon Health and Science University$$041354$$10000-0003-4174-5562
000042699 7201_ $$uOregon Health and Science University$$041354$$7Personal$$eMentor
000042699 8564_ $$yPAF 2024 PhD Thesis$$94a9b19a4-4eba-4830-99e1-fdd577da3ea3$$s8856571$$uhttps://digitalcollections.ohsu.edu/record/42699/files/Flynn.Patrick.2024.pdf$$ePublic$$245e515e43d6797e154ac127ffd755ffc$$31
000042699 909CO $$ooai:digitalcollections.ohsu.edu:42699$$pstudent-work
000042699 980__ $$aTheses and Dissertations
000042699 981__ $$aPublished$$b2024-02-28