000042751 001__ 42751
000042751 005__ 20240318123702.0
000042751 0247_ $$2doi$$a10.6083/bpxhc42751
000042751 037__ $$aETD
000042751 041__ $$aeng
000042751 245__ $$aA functional role for Dystroglycan at inhibitory synapses across multiple brain regions
000042751 260__ $$bOregon Health and Science University
000042751 269__ $$a2024-03-15
000042751 336__ $$aDissertation
000042751 502__ $$bPh.D.
000042751 502__ $$gNeuroscience
000042751 520__ $$aDuring neural development cells must migrate to the appropriate destination and establish connections with the appropriate cell types. The cell adhesion molecule Dystroglycan has been shown to be involved in neural migration and axon targeting in multiple brain regions. In the hippocampus, Dystroglycan is involved in CCK+ basket axon targeting of pyramidal cells in CA1-3. In this dissertation, I show that Dystroglycan is also required for the function of these CCK+ basket synapses in a manner dependent on both the extracellular glycosylation of Dystroglycan and intracellular interactions with Dystroglycan. Similarly, I show that Dystroglycan is also located at cerebellar molecular layer interneuron synapses onto Purkinje cells and is required for the function of these synapses in a mechanism that mirrors that in the hippocampus. Finally, I identify Cntnap1 as a novel interacting partner of Dystroglycan in the brain.
000042751 540__ $$fCC BY
000042751 542__ $$fIn copyright - single owner
000042751 650__ $$aInterneurons$$020936
000042751 650__ $$aSynapses$$026704
000042751 650__ $$aPurkinje Cells$$024938
000042751 650__ $$aDystroglycans$$036156
000042751 6531_ $$aCntnap1
000042751 691__ $$aSchool of Medicine$$041369
000042751 692__ $$aVollum Institute$$041509
000042751 7001_ $$aJahncke, Jennifer$$uOregon Health and Science University$$041354$$10000-0003-2319-6109
000042751 8564_ $$93c726649-d8b2-41e2-b81e-031acf09c657$$s22799728$$uhttps://digitalcollections.ohsu.edu/record/42751/files/Jahncke.Jennifer.2024.pdf
000042751 909CO $$ooai:digitalcollections.ohsu.edu:42751$$pstudent-work
000042751 980__ $$aTheses and Dissertations
000042751 981__ $$aPublished$$b2024-03-18