TY - GEN N2 - Tuberculosis (TB) is a devastating illness. In the search for novel anti-TB therapies, there is growing interest in host-directed therapy (HDT), which seeks to synergize with frontline antibiotics by altering the host conditions – making us a less hospitable host – and re-sensitizing the bacteria to antibiotic therapy. This dissertation project lies at the intersection between two understudied fields: host-pathogen interactions and sphingolipids during Mycobacterium tuberculosis infection. AB - Tuberculosis (TB) is a devastating illness. In the search for novel anti-TB therapies, there is growing interest in host-directed therapy (HDT), which seeks to synergize with frontline antibiotics by altering the host conditions – making us a less hospitable host – and re-sensitizing the bacteria to antibiotic therapy. This dissertation project lies at the intersection between two understudied fields: host-pathogen interactions and sphingolipids during Mycobacterium tuberculosis infection. AD - Oregon Health and Science University T1 - TB and the sphinx: an investigation into the ways host sphingolipids affect mycobacterium tuberculosis infection ED - Tafesse, Fikadu G. ED - Mentor DA - 2024-02-16 AU - Guzman, Gaelen L1 - https://digitalcollections.ohsu.edu/record/42887/files/Guzman.Gaelen.2024.pdf PB - Oregon Health and Science University LA - eng PY - 2024-02-16 ID - 42887 L4 - https://digitalcollections.ohsu.edu/record/42887/files/Guzman.Gaelen.2024.pdf KW - Mycobacterium tuberculosis KW - Sphingolipids KW - Lipidomics KW - Proteomics KW - Host-Pathogen Interactions KW - Phagocytosis KW - membrane repair KW - systematic review TI - TB and the sphinx: an investigation into the ways host sphingolipids affect mycobacterium tuberculosis infection Y1 - 2024-02-16 L2 - https://digitalcollections.ohsu.edu/record/42887/files/Guzman.Gaelen.2024.pdf LK - https://digitalcollections.ohsu.edu/record/42887/files/Guzman.Gaelen.2024.pdf UR - https://digitalcollections.ohsu.edu/record/42887/files/Guzman.Gaelen.2024.pdf ER -