000042887 001__ 42887
000042887 005__ 20240507124421.0
000042887 037__ $$aETD
000042887 041__ $$aeng
000042887 245__ $$aTB and the sphinx: an investigation into the ways host sphingolipids affect mycobacterium tuberculosis infection
000042887 260__ $$bOregon Health and Science University
000042887 269__ $$a2024-02-16
000042887 336__ $$aDissertation
000042887 502__ $$bPh.D.
000042887 502__ $$gMolecular Microbiology & Immunology
000042887 520__ $$aTuberculosis (TB) is a devastating illness. In the search for novel anti-TB therapies, there is growing interest in host-directed therapy (HDT), which seeks to synergize with frontline antibiotics by altering the host conditions – making us a less hospitable host – and re-sensitizing the bacteria to antibiotic therapy. This dissertation project lies at the intersection between two understudied fields: host-pathogen interactions and sphingolipids during Mycobacterium tuberculosis infection.
000042887 540__ $$fCC BY
000042887 542__ $$fIn copyright - single owner
000042887 650__ $$aMycobacterium tuberculosis$$022570
000042887 650__ $$aSphingolipids$$026271
000042887 650__ $$aLipidomics$$013258
000042887 650__ $$aProteomics$$035059
000042887 650__ $$aHost-Pathogen Interactions$$038099
000042887 650__ $$aPhagocytosis$$023897
000042887 6531_ $$amembrane repair
000042887 6531_ $$asystematic review
000042887 691__ $$aSchool of Medicine$$041369
000042887 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000042887 7001_ $$aGuzman, Gaelen $$uOregon Health and Science University$$041354$$10000-0002-7696-6034
000042887 7201_ $$aTafesse, Fikadu G.$$uOregon Health and Science University$$041354$$10000-0002-8575-4164$$eMentor$$7Personal
000042887 789__ $$eIs variant of$$2URL
000042887 8564_ $$9cb24ba6d-7450-4829-aa51-a4dfe59d020d$$s115657102$$uhttps://digitalcollections.ohsu.edu/record/42887/files/Guzman.Gaelen.2024.pdf
000042887 909CO $$ooai:digitalcollections.ohsu.edu:42887$$pstudent-work
000042887 980__ $$aTheses and Dissertations
000042887 981__ $$aPublished$$b2024-05-07