@article{ETD,
      school = {Ph.D.},
      author = {Ray, Michael},
      url = {http://digitalcollections.ohsu.edu/record/42915},
      title = {The role of antimicrobial stewardship in modifying the  epidemiology of clostridioides difficile infection},
      publisher = {Oregon Health and Science University},
      abstract = {Clostridioides difficile infection (CDI) causes nearly  half a million diarrheal illnesses annually in the United  States and is associated with a twofold increase in the  risk of death for hospitalized patients with CDI. Broad  spectrum antibiotic therapy is a major risk factor for CDI.  As such, healthcare-associated (HA) CDI is often employed  as a metric to evaluate antimicrobial stewardship programs  (ASPs). However, because the risk from antibiotics is  heterogeneous and dependent on a variety of other  individual and environmental risk factors, evidence that  HA-CDI is a quality metric for stewardship success is  lacking. The objective of this dissertation is to achieve a  more granular understanding of the risk of HA-CDI from  antibiotics, and to evaluate the specific contexts where we  would expect HA-CDI incidence to reflect changes in broad  spectrum prescribing through stewardship interventions. 
},
      number = {ETD},
      doi = {https://doi.org/10.6083/bpxhc42915},
      recid = {42915},
      address = {2024-05-29},
}