TY  - GEN
N2  - Globally, Taenia solium contributes to an estimated 2.8 million disability-adjusted life years per year, the most significant public health burden of any foodborne parasite. In communities where T. solium is endemic, the dual threat of taeniasis (the intestinal infection) and epilepsy caused by neurocysticercosis (NCC, the central nervous system [CNS] infection) causes extensive population morbidity and complicates community-based health care delivery. Despite its impact, as a neglected tropical disease, the available evidence on safe and appropriate healthcare practices for T. solium-related diseases also remains neglected. This dissertation research addresses these gaps by 1) describing the prevalence of viable NCC among individuals being considered for treatment of taeniasis, 2) assessing the relationship between NCC and time to seizure control among people with epilepsy initiating ASM treatment, and 3) examining the association between the epilepsy treatment gap and health related quality of life, stratified by NCC. All three aims represent populations living in Northern Peru – an area highly endemic with T. solium.
AB  - Globally, Taenia solium contributes to an estimated 2.8 million disability-adjusted life years per year, the most significant public health burden of any foodborne parasite. In communities where T. solium is endemic, the dual threat of taeniasis (the intestinal infection) and epilepsy caused by neurocysticercosis (NCC, the central nervous system [CNS] infection) causes extensive population morbidity and complicates community-based health care delivery. Despite its impact, as a neglected tropical disease, the available evidence on safe and appropriate healthcare practices for T. solium-related diseases also remains neglected. This dissertation research addresses these gaps by 1) describing the prevalence of viable NCC among individuals being considered for treatment of taeniasis, 2) assessing the relationship between NCC and time to seizure control among people with epilepsy initiating ASM treatment, and 3) examining the association between the epilepsy treatment gap and health related quality of life, stratified by NCC. All three aims represent populations living in Northern Peru – an area highly endemic with T. solium.
AD  - Oregon Health and Science University
T1  - Understanding the availability and use of pharmacotherapy interventions for Taenia solium related diseases in Northern Peru
DA  - 2024-05-30
AU  - Wardle, Melissa
L1  - https://digitalcollections.ohsu.edu/record/42947/files/Wardle.Melissa.2024.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2024-05-30
ID  - 42947
L4  - https://digitalcollections.ohsu.edu/record/42947/files/Wardle.Melissa.2024.pdf
KW  - Neglected Diseases
KW  - Neurocysticercosis
KW  - Taenia solium
KW  - Taeniasis
KW  - Parasites
KW  - Praziquantel
KW  - Albendazole
KW  - Niclosamide
KW  - Epilepsy
KW  - Seizures
KW  - Anticonvulsants
KW  - pharmacotherapy intervention
TI  - Understanding the availability and use of pharmacotherapy interventions for Taenia solium related diseases in Northern Peru
Y1  - 2024-05-30
L2  - https://digitalcollections.ohsu.edu/record/42947/files/Wardle.Melissa.2024.pdf
LK  - https://digitalcollections.ohsu.edu/record/42947/files/Wardle.Melissa.2024.pdf
UR  - https://digitalcollections.ohsu.edu/record/42947/files/Wardle.Melissa.2024.pdf
ER  -