000042947 001__ 42947
000042947 005__ 20240604124811.0
000042947 037__ $$aETD
000042947 041__ $$aeng
000042947 245__ $$aUnderstanding the availability and use of pharmacotherapy interventions for Taenia solium related diseases in Northern Peru
000042947 260__ $$bOregon Health and Science University
000042947 269__ $$a2024-05-30
000042947 336__ $$aDissertation
000042947 502__ $$bPh.D.
000042947 502__ $$gEpidemiology
000042947 520__ $$aGlobally, Taenia solium contributes to an estimated 2.8 million disability-adjusted life years per year, the most significant public health burden of any foodborne parasite. In communities where T. solium is endemic, the dual threat of taeniasis (the intestinal infection) and epilepsy caused by neurocysticercosis (NCC, the central nervous system [CNS] infection) causes extensive population morbidity and complicates community-based health care delivery. Despite its impact, as a neglected tropical disease, the available evidence on safe and appropriate healthcare practices for T. solium-related diseases also remains neglected. This dissertation research addresses these gaps by 1) describing the prevalence of viable NCC among individuals being considered for treatment of taeniasis, 2) assessing the relationship between NCC and time to seizure control among people with epilepsy initiating ASM treatment, and 3) examining the association between the epilepsy treatment gap and health related quality of life, stratified by NCC. All three aims represent populations living in Northern Peru – an area highly endemic with T. solium.
000042947 540__ $$fCC BY
000042947 542__ $$fIn copyright - single owner
000042947 650__ $$aNeglected Diseases$$039082
000042947 650__ $$aNeurocysticercosis$$032065
000042947 650__ $$aTaenia solium$$035080
000042947 650__ $$aTaeniasis$$026750
000042947 650__ $$aParasites$$023589
000042947 650__ $$aPraziquantel$$024501
000042947 650__ $$aAlbendazole$$028630
000042947 650__ $$aNiclosamide$$022900
000042947 650__ $$aEpilepsy$$018531
000042947 650__ $$aSeizures$$025832
000042947 650__ $$aAnticonvulsants$$014870
000042947 651__ $$aPeru$$041104
000042947 6531_ $$apharmacotherapy intervention
000042947 691__ $$aOHSU-PSU School of Public Health$$041366
000042947 7001_ $$aWardle, Melissa$$uOregon Health and Science University$$041354$$10000-0001-5002-8368
000042947 8564_ $$9281a35e4-6406-42bf-bb3b-dbddd8327daa$$s2786010$$uhttps://digitalcollections.ohsu.edu/record/42947/files/Wardle.Melissa.2024.pdf
000042947 909CO $$ooai:digitalcollections.ohsu.edu:42947$$pstudent-work
000042947 980__ $$aTheses and Dissertations
000042947 981__ $$aPublished$$b2024-06-03