000043379 001__ 43379 000043379 005__ 20240614124957.0 000043379 0247_ $$2doi$$a10.6083/bpxhc43379 000043379 037__ $$aETD 000043379 041__ $$aeng 000043379 245__ $$aMulti-parametric MRI fingerprinting analysis of pancreatic lesions with ferumoxytol contrast for correlation with vascular structure 000043379 260__ $$bOregon Health and Science University 000043379 269__ $$a2024-06-07 000043379 336__ $$aThesis 000043379 502__ $$bM.S. 000043379 502__ $$gMedical Physics 000043379 520__ $$aThe aim of this research is to utilize MRF techniques to characterize vascularization differences between healthy pancreas tissue and tumorous tissue. To do this, both healthy volunteers and cancer patients eligible for surgery were scanned using contrast generated by iron nanoparticles (Ferumoxytol), and values for T1, T2 and T2* were extracted from a dictionary fitting. A secondary aim of this project was to analyze the differences between breath hold and free breathing techniques in MRF scans, thus scans were completed with both breath holds and free breathing. 000043379 540__ $$fCC BY 000043379 542__ $$fPublic domain 000043379 650__ $$aMagnetic Resonance Imaging$$021747 000043379 650__ $$aPancreatic Neoplasms$$023517 000043379 6531_ $$aMRI 000043379 6531_ $$apancreatic cancer 000043379 6531_ $$afingerprinting 000043379 6531_ $$aferumoxytol 000043379 6531_ $$aferaheme 000043379 691__ $$aSchool of Medicine$$041369 000043379 7001_ $$aBarton, Zachary J.$$uOregon Health and Science University$$041354$$10009-0004-2232-7941 000043379 7201_ $$aWyatt, Cory R.$$uOregon Health and Science University$$041354$$10000-0001-7050-3365$$eMentor$$7Personal 000043379 7201_ $$aGuimaraes, Alexander R.$$uOregon Health and Science University$$041354$$10000-0003-4601-9340$$eCo-Mentor$$7Personal 000043379 7201_ $$aChang, Young Hwan$$uOregon Health and Science University$$041354$$10000-0001-8764-1959$$eCommittee member$$7Personal 000043379 7201_ $$aMench, M. Anna$$uOregon Health and Science University$$041354$$eCommittee chair$$7Personal 000043379 8564_ $$yFigures Copyright Permission-Bushberg$$9e6d4ab78-7152-410d-ae72-36946ed15ea7$$s195437$$uhttps://digitalcollections.ohsu.edu/record/43379/files/Bushberg%20Printable%20License.pdf 000043379 8564_ $$91e881dde-476a-4a72-95ff-8f363c46b25d$$s708410$$uhttps://digitalcollections.ohsu.edu/record/43379/files/Barton.Zachary.2024.pdf 000043379 909CO $$ooai:digitalcollections.ohsu.edu:43379$$pstudent-work 000043379 980__ $$aTheses and Dissertations 000043379 981__ $$aPublished$$b2024-06-14