@article{ETD,
      school = {Ph.D.},
      author = {McClatchy, John},
      url = {http://digitalcollections.ohsu.edu/record/43391},
      title = {IL1β driven transcriptomic and epigenetic mechanisms  regulating lineage bias and myeloid expansion of  hematopoietic cells with TET2 loss-of-function},
      publisher = {Oregon Health and Science University},
      abstract = {Clonal hematopoiesis (CH) involves a single hematopoietic  stem/progenitor cell (HSPC) gaining a selective advantage  due to somatic mutations, increasing the risk of  hematological malignancies and cardiovascular disease. In  murine models of CHIP with Tet2 deletion, the  proinflammatory cytokine IL1β promotes the expansion of  pro-inflammatory monocytes/macrophages and hinder  demethylation of enhancers and transcription factor binding  sites associated with lymphoid and erythroid  differentiation. This work suggests that IL1β enhances the  self-renewing ability of Tet2-deficient HSPCs by  upregulating self-renewal genes and resisting  demethylation, highlighting IL1 signaling as a potential  target for early intervention in preleukemic  disorders.




},
      number = {ETD},
      doi = {https://doi.org/10.6083/bpxhc43391},
      recid = {43391},
      address = {2024-06-14},
}