TY  - THES
N2  - Clonal hematopoiesis (CH) involves a single hematopoietic stem/progenitor cell (HSPC) gaining a selective advantage due to somatic mutations, increasing the risk of hematological malignancies and cardiovascular disease. In murine models of CHIP with Tet2 deletion, the proinflammatory cytokine IL1β promotes the expansion of pro-inflammatory monocytes/macrophages and hinder demethylation of enhancers and transcription factor binding sites associated with lymphoid and erythroid differentiation. This work suggests that IL1β enhances the self-renewing ability of Tet2-deficient HSPCs by upregulating self-renewal genes and resisting demethylation, highlighting IL1 signaling as a potential target for early intervention in preleukemic disorders.





DO  - 10.6083/bpxhc43391
DO  - doi
AB  - Clonal hematopoiesis (CH) involves a single hematopoietic stem/progenitor cell (HSPC) gaining a selective advantage due to somatic mutations, increasing the risk of hematological malignancies and cardiovascular disease. In murine models of CHIP with Tet2 deletion, the proinflammatory cytokine IL1β promotes the expansion of pro-inflammatory monocytes/macrophages and hinder demethylation of enhancers and transcription factor binding sites associated with lymphoid and erythroid differentiation. This work suggests that IL1β enhances the self-renewing ability of Tet2-deficient HSPCs by upregulating self-renewal genes and resisting demethylation, highlighting IL1 signaling as a potential target for early intervention in preleukemic disorders.





AD  - Oregon Health and Science University
T1  - IL1β driven transcriptomic and epigenetic mechanisms regulating lineage bias and myeloid expansion of hematopoietic cells with TET2 loss-of-function
ED  - Agarwal, Anupriya
ED  - Academic advisor
DA  - 2024-06-14
AU  - McClatchy, John
L1  - https://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2024-06-14
ID  - 43391
L4  - https://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
KW  - Clonal Hematopoiesis
KW  - Hematopoiesis
KW  - Inflammation
KW  - Inflammation
TI  - IL1β driven transcriptomic and epigenetic mechanisms regulating lineage bias and myeloid expansion of hematopoietic cells with TET2 loss-of-function
Y1  - 2024-06-14
L2  - https://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
LK  - https://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
UR  - https://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
ER  -