TY  - THES
AB  - Clonal hematopoiesis (CH) involves a single hematopoietic stem/progenitor cell (HSPC) gaining a selective advantage due to somatic mutations, increasing the risk of hematological malignancies and cardiovascular disease. In murine models of CHIP with Tet2 deletion, the proinflammatory cytokine IL1β promotes the expansion of pro-inflammatory monocytes/macrophages and hinder demethylation of enhancers and transcription factor binding sites associated with lymphoid and erythroid differentiation. This work suggests that IL1β enhances the self-renewing ability of Tet2-deficient HSPCs by upregulating self-renewal genes and resisting demethylation, highlighting IL1 signaling as a potential target for early intervention in preleukemic disorders.
AD  - Oregon Health and Science University
AU  - McClatchy, John
DA  - 2024-06-14
DO  - 10.6083/bpxhc43391
DO  - doi
ED  - Agarwal, Anupriya
ED  - Academic advisor
ID  - 43391
KW  - Clonal Hematopoiesis
KW  - Hematopoiesis
KW  - Inflammation
KW  - Inflammation
L1  - https://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
L2  - https://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
L4  - https://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
N2  - Clonal hematopoiesis (CH) involves a single hematopoietic stem/progenitor cell (HSPC) gaining a selective advantage due to somatic mutations, increasing the risk of hematological malignancies and cardiovascular disease. In murine models of CHIP with Tet2 deletion, the proinflammatory cytokine IL1β promotes the expansion of pro-inflammatory monocytes/macrophages and hinder demethylation of enhancers and transcription factor binding sites associated with lymphoid and erythroid differentiation. This work suggests that IL1β enhances the self-renewing ability of Tet2-deficient HSPCs by upregulating self-renewal genes and resisting demethylation, highlighting IL1 signaling as a potential target for early intervention in preleukemic disorders.
PB  - Oregon Health and Science University
PY  - 2024-06-14
T1  - IL1β driven transcriptomic and epigenetic mechanisms regulating lineage bias and myeloid expansion of hematopoietic cells with TET2 loss-of-function
TI  - IL1β driven transcriptomic and epigenetic mechanisms regulating lineage bias and myeloid expansion of hematopoietic cells with TET2 loss-of-function
UR  - https://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
Y1  - 2024-06-14
ER  -