000043391 001__ 43391
000043391 005__ 20240617125019.0
000043391 0247_ $$2doi$$a10.6083/bpxhc43391
000043391 037__ $$aETD
000043391 041__ $$aeng
000043391 245__ $$aIL1β driven transcriptomic and epigenetic mechanisms regulating lineage bias and myeloid expansion of hematopoietic cells with TET2 loss-of-function
000043391 260__ $$bOregon Health and Science University
000043391 269__ $$a2024-06-14
000043391 336__ $$aThesis
000043391 502__ $$bPh.D.
000043391 502__ $$gCancer Biology
000043391 520__ $$aClonal hematopoiesis (CH) involves a single hematopoietic stem/progenitor cell (HSPC) gaining a selective advantage due to somatic mutations, increasing the risk of hematological malignancies and cardiovascular disease. In murine models of CHIP with Tet2 deletion, the proinflammatory cytokine IL1β promotes the expansion of pro-inflammatory monocytes/macrophages and hinder demethylation of enhancers and transcription factor binding sites associated with lymphoid and erythroid differentiation. This work suggests that IL1β enhances the self-renewing ability of Tet2-deficient HSPCs by upregulating self-renewal genes and resisting demethylation, highlighting IL1 signaling as a potential target for early intervention in preleukemic disorders.





000043391 540__ $$fCC BY
000043391 542__ $$fPublic domain
000043391 650__ $$aClonal Hematopoiesis$$013302
000043391 650__ $$aHematopoiesis$$020014
000043391 650__ $$aInflammation$$020800
000043391 6531_ $$aInflammation
000043391 691__ $$aSchool of Medicine$$041369
000043391 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000043391 7001_ $$aMcClatchy, John$$uOregon Health and Science University$$041354$$10000-0001-5531-6115
000043391 7201_ $$aAgarwal, Anupriya$$uOregon Health and Science University$$041354$$10000-0001-8678-0519$$eAcademic advisor$$7Personal
000043391 8564_ $$94ee4ac87-f2bb-4791-84f3-572e6b3f5824$$s4048283$$uhttps://digitalcollections.ohsu.edu/record/43391/files/McClatchy.John.2024.pdf
000043391 909CO $$ooai:digitalcollections.ohsu.edu:43391$$pstudent-work
000043391 980__ $$aTheses and Dissertations
000043391 981__ $$aPublished$$b2024-06-17