TY - THES N2 - The nucleus accumbens plays a key role in guiding motivated behavior by integrating glutamate inputs, the major driver of neuronal activation, and dopamine (DA) inputs, a critical source of neuronal modulation. Therefore, it is important to understand how glutamate and DA transmission interact, particularly in reward-seeking behavior. Substance use disorder (SUD) is a brain disease in which reward-seeking becomes dysregulated. In this dissertation, I use fiber photometry to extend our understanding of this interaction during two reward-seeking tasks. DO - 10.6083/bpxhc43430 DO - doi AB - The nucleus accumbens plays a key role in guiding motivated behavior by integrating glutamate inputs, the major driver of neuronal activation, and dopamine (DA) inputs, a critical source of neuronal modulation. Therefore, it is important to understand how glutamate and DA transmission interact, particularly in reward-seeking behavior. Substance use disorder (SUD) is a brain disease in which reward-seeking becomes dysregulated. In this dissertation, I use fiber photometry to extend our understanding of this interaction during two reward-seeking tasks. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University T1 - The role of nucleus accumbens dopamine in incubation of cocaine craving DA - 2024-06-20 AU - Weber, Sophia AU - Kawa, Alex AU - Moutier, Alana AU - Beutler, Madelyn AU - Koyshman, Lara AU - Moreno, Cloe AU - Westlake, Jonathan AU - Driscoll, Gillian AU - Kuhn, Hayley AU - Wolf, Marina L1 - https://digitalcollections.ohsu.edu/record/43430/files/Weber.Sophia.2024.pdf PB - Oregon Health and Science University LA - eng PY - 2024-06-20 ID - 43430 L4 - https://digitalcollections.ohsu.edu/record/43430/files/Weber.Sophia.2024.pdf KW - Behavior, Addictive KW - Dopamine KW - Cocaine KW - incubation of drug craving KW - fiber photometry KW - behavioral pharmacology TI - The role of nucleus accumbens dopamine in incubation of cocaine craving Y1 - 2024-06-20 L2 - https://digitalcollections.ohsu.edu/record/43430/files/Weber.Sophia.2024.pdf LK - https://digitalcollections.ohsu.edu/record/43430/files/Weber.Sophia.2024.pdf UR - https://digitalcollections.ohsu.edu/record/43430/files/Weber.Sophia.2024.pdf ER -