000043430 001__ 43430 000043430 005__ 20240620125041.0 000043430 0247_ $$2doi$$a10.6083/bpxhc43430 000043430 037__ $$aETD 000043430 041__ $$aeng 000043430 245__ $$a The role of nucleus accumbens dopamine in incubation of cocaine craving 000043430 260__ $$bOregon Health and Science University 000043430 269__ $$a2024-06-20 000043430 336__ $$aThesis 000043430 502__ $$bPh.D. 000043430 502__ $$gBehavioral & Systems Neuroscience 000043430 520__ $$aThe nucleus accumbens plays a key role in guiding motivated behavior by integrating glutamate inputs, the major driver of neuronal activation, and dopamine (DA) inputs, a critical source of neuronal modulation. Therefore, it is important to understand how glutamate and DA transmission interact, particularly in reward-seeking behavior. Substance use disorder (SUD) is a brain disease in which reward-seeking becomes dysregulated. In this dissertation, I use fiber photometry to extend our understanding of this interaction during two reward-seeking tasks. 000043430 536__ $$oNIDA$$cDA007262 000043430 536__ $$oNIDA$$cDA057063 000043430 540__ $$fCC BY 000043430 542__ $$fPublic domain 000043430 650__ $$aBehavior, Addictive$$029367 000043430 650__ $$aDopamine$$018026 000043430 650__ $$aCocaine$$016839 000043430 651__ $$aOregon$$041094 000043430 6531_ $$aincubation of drug craving 000043430 6531_ $$afiber photometry 000043430 6531_ $$abehavioral pharmacology 000043430 691__ $$aSchool of Medicine$$041369 000043430 692__ $$aDepartment of Behavioral Neuroscience$$041394 000043430 7001_ $$aWeber, Sophia$$uOregon Health and Science University$$041354$$10000-0002-0845-7385 000043430 7001_ $$aKawa, Alex$$uOregon Health and Science University$$041354$$10000-0002-8870-0233 000043430 7001_ $$aMoutier, Alana$$uOregon Health and Science University$$041354$$10009-0005-3336-8498 000043430 7001_ $$aBeutler, Madelyn$$uOregon Health and Science University$$041354 000043430 7001_ $$aKoyshman, Lara$$uOregon Health and Science University$$041354 000043430 7001_ $$aMoreno, Cloe$$uOregon Health and Science University$$041354$$10009-0006-2389-2074 000043430 7001_ $$aWestlake, Jonathan$$uOregon Health and Science University$$041354 000043430 7001_ $$aDriscoll, Gillian$$uOregon Health and Science University$$041354$$10000-0003-1905-2620 000043430 7001_ $$aKuhn, Hayley$$uOregon Health and Science University$$041354$$10000-0003-1315-4685 000043430 7001_ $$aWolf, Marina$$uOregon Health and Science University$$041354 000043430 8564_ $$yThesis$$9f431913f-988d-46cc-b0da-c5aac466ab60$$s3677469$$uhttps://digitalcollections.ohsu.edu/record/43430/files/Weber.Sophia.2024.pdf 000043430 909CO $$ooai:digitalcollections.ohsu.edu:43430$$pstudent-work 000043430 980__ $$aTheses and Dissertations 000043430 981__ $$aPublished$$b2024-06-20