@article{ETD,
      school = {Ph.D.},
      author = {Korzun, Tetiana},
      url = {http://digitalcollections.ohsu.edu/record/43436},
      title = {Navigating challenges in mRNA lipid nanoparticle  therapeutics for metastatic epithelial cancers},
      publisher = {Oregon Health and Science University},
      abstract = {Cachexia and cancer, when intertwined, precipitate severe  adverse outcomes for patients, underscoring the urgent need  for innovative therapeutic strategies. This dissertation  addresses a significant gap in current treatments for  metastatic epithelial cancers that overexpress activin A, a  therapeutic target implicated in the propagation of  tumorigenesis, metastatic spread, and cancer-associated  cachexia. Activin A overexpression is a common denominator  in various epithelial malignancies, including prostate,  pancreatic, colorectal, lung, head and neck, liver cancers,  and, notably, epithelial ovarian carcinoma - the focal  point of this dissertation. At the heart of this research  is developing and optimizing a novel lipid  nanoparticle-based formulation for delivering follistatin  mRNA aimed at neutralizing activin A by sequestering it in  an inactive state. },
      number = {ETD},
      recid = {43436},
      address = {2024-06-20},
}