TY  - GEN
N2  - Cachexia and cancer, when intertwined, precipitate severe adverse outcomes for patients, underscoring the urgent need for innovative therapeutic strategies. This dissertation addresses a significant gap in current treatments for metastatic epithelial cancers that overexpress activin A, a therapeutic target implicated in the propagation of tumorigenesis, metastatic spread, and cancer-associated cachexia. Activin A overexpression is a common denominator in various epithelial malignancies, including prostate, pancreatic, colorectal, lung, head and neck, liver cancers, and, notably, epithelial ovarian carcinoma - the focal point of this dissertation. At the heart of this research is developing and optimizing a novel lipid nanoparticle-based formulation for delivering follistatin mRNA aimed at neutralizing activin A by sequestering it in an inactive state. 
AB  - Cachexia and cancer, when intertwined, precipitate severe adverse outcomes for patients, underscoring the urgent need for innovative therapeutic strategies. This dissertation addresses a significant gap in current treatments for metastatic epithelial cancers that overexpress activin A, a therapeutic target implicated in the propagation of tumorigenesis, metastatic spread, and cancer-associated cachexia. Activin A overexpression is a common denominator in various epithelial malignancies, including prostate, pancreatic, colorectal, lung, head and neck, liver cancers, and, notably, epithelial ovarian carcinoma - the focal point of this dissertation. At the heart of this research is developing and optimizing a novel lipid nanoparticle-based formulation for delivering follistatin mRNA aimed at neutralizing activin A by sequestering it in an inactive state. 
AD  - Oregon Health and Science University
T1  - Navigating challenges in mRNA lipid nanoparticle therapeutics for metastatic epithelial cancers
DA  - 2024-06-20
AU  - Korzun, Tetiana
L1  - https://digitalcollections.ohsu.edu/record/43436/files/Korzun.Tetiana.2024.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2024-06-20
ID  - 43436
L4  - https://digitalcollections.ohsu.edu/record/43436/files/Korzun.Tetiana.2024.pdf
KW  - Nanomedicine
KW  - Carcinoma
KW  - Cachexia
KW  -  lipid nanoparticles
KW  - mRNA therapy
TI  - Navigating challenges in mRNA lipid nanoparticle therapeutics for metastatic epithelial cancers
Y1  - 2024-06-20
L2  - https://digitalcollections.ohsu.edu/record/43436/files/Korzun.Tetiana.2024.pdf
LK  - https://digitalcollections.ohsu.edu/record/43436/files/Korzun.Tetiana.2024.pdf
UR  - https://digitalcollections.ohsu.edu/record/43436/files/Korzun.Tetiana.2024.pdf
ER  -