000043436 001__ 43436
000043436 005__ 20240622125049.0
000043436 037__ $$aETD
000043436 041__ $$aeng
000043436 245__ $$aNavigating challenges in mRNA lipid nanoparticle therapeutics for metastatic epithelial cancers
000043436 260__ $$bOregon Health and Science University
000043436 269__ $$a2024-06-20
000043436 336__ $$aDissertation
000043436 502__ $$bPh.D.
000043436 502__ $$gBiomedical Engineering
000043436 520__ $$aCachexia and cancer, when intertwined, precipitate severe adverse outcomes for patients, underscoring the urgent need for innovative therapeutic strategies. This dissertation addresses a significant gap in current treatments for metastatic epithelial cancers that overexpress activin A, a therapeutic target implicated in the propagation of tumorigenesis, metastatic spread, and cancer-associated cachexia. Activin A overexpression is a common denominator in various epithelial malignancies, including prostate, pancreatic, colorectal, lung, head and neck, liver cancers, and, notably, epithelial ovarian carcinoma - the focal point of this dissertation. At the heart of this research is developing and optimizing a novel lipid nanoparticle-based formulation for delivering follistatin mRNA aimed at neutralizing activin A by sequestering it in an inactive state. 
000043436 540__ $$fCC BY
000043436 542__ $$fPublic domain
000043436 650__ $$aNanomedicine$$036670
000043436 650__ $$aCarcinoma$$016112
000043436 650__ $$aCachexia$$015945
000043436 6531_ $$a lipid nanoparticles
000043436 6531_ $$amRNA therapy
000043436 691__ $$aSchool of Medicine$$041369
000043436 692__ $$aDepartment of Biomedical Engineering$$041397
000043436 7001_ $$aKorzun, Tetiana$$uOregon Health and Science University$$041354
000043436 8564_ $$96376ef67-62ba-449e-b489-ed4c8af90bc9$$s61298675$$uhttps://digitalcollections.ohsu.edu/record/43436/files/Korzun.Tetiana.2024.pdf
000043436 909CO $$ooai:digitalcollections.ohsu.edu:43436$$pstudent-work
000043436 980__ $$aTheses and Dissertations
000043436 981__ $$aPublished$$b2024-06-21