000043526 001__ 43526 000043526 005__ 20240720125441.0 000043526 0247_ $$2doi$$a10.6083/bpxhc43526 000043526 037__ $$aETD 000043526 041__ $$aeng 000043526 245__ $$aMechanisms of polydispersity and client-induced co-aggregation of small heat shock proteins 000043526 260__ $$bOregon Health and Science University 000043526 269__ $$a2024-07-19 000043526 336__ $$aDissertation 000043526 502__ $$bPh.D. 000043526 502__ $$gBiomedical Sciences 000043526 520__ $$aWork presented in this dissertation describe mechanisms of oligomeric polydispersity and client-binding by various small heat shock proteins (alpha-crystallins, HSP16.5) using single particle EM approaches (CryoEM, NS-EM). 000043526 536__ $$oNIH$$cF31-EY033226-03 000043526 540__ $$fCC BY 000043526 542__ $$fPublic domain 000043526 650__ $$aHeat-Shock Proteins, Small$$036620 000043526 650__ $$aMolecular Chaperones$$031132 000043526 6531_ $$asHSP 000043526 6531_ $$aprotein aggregation 000043526 691__ $$aSchool of Medicine$$041369 000043526 692__ $$aDepartment of Chemical Physiology and Biochemistry$$041400 000043526 7001_ $$aMiller, Adam$$uOregon Health and Science University$$041354$$10000-0002-9676-4253 000043526 8564_ $$9b49a8440-58db-40dc-b95c-221109e819a1$$s32525451$$uhttps://digitalcollections.ohsu.edu/record/43526/files/Miller.Adam.2024.pdf 000043526 909CO $$ooai:digitalcollections.ohsu.edu:43526$$pstudent-work 000043526 980__ $$aTheses and Dissertations 000043526 981__ $$aPublished$$b2024-07-19