TY  - GEN
N2  - Effective treatments for methamphetamine (MA)-use disorder (MUD) are critically needed. Treatment outcomes, however, are variable, especially for women, as sex differences in treatment efficacy have not been adequately studied. With rates of MUD recently tripling in women, it's critical to identify sex-specific mechanisms and targets for tailored medications. Women exhibit higher levels of inflammation and greater activation in emotional centers of the brain. These differences may explain why women resort to MA more frequently to alleviate negative emotions. Despite evidence of sex differences in biological mechanisms, there is a lack of studies extending these results in MUD. This proposal therefore aims to address the knowledge gap in sex differences in MUD, focusing on inflammation and brain function.
DO  - 10.6083/bpxhc43552
DO  - doi
AB  - Effective treatments for methamphetamine (MA)-use disorder (MUD) are critically needed. Treatment outcomes, however, are variable, especially for women, as sex differences in treatment efficacy have not been adequately studied. With rates of MUD recently tripling in women, it's critical to identify sex-specific mechanisms and targets for tailored medications. Women exhibit higher levels of inflammation and greater activation in emotional centers of the brain. These differences may explain why women resort to MA more frequently to alleviate negative emotions. Despite evidence of sex differences in biological mechanisms, there is a lack of studies extending these results in MUD. This proposal therefore aims to address the knowledge gap in sex differences in MUD, focusing on inflammation and brain function.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Sex differences in inflammation and brain function in methamphetamine use disorder
DA  - 2024
AU  - Sonnon, Alea
AU  - Nagum, Jazryn
AU  - Dennis, Laura
AU  - Kohno, Milky
L1  - https://digitalcollections.ohsu.edu/record/43552/files/ResearchWeek.2024.Sonnon.Alea.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2024
ID  - 43552
L4  - https://digitalcollections.ohsu.edu/record/43552/files/ResearchWeek.2024.Sonnon.Alea.pdf
KW  - Methamphetamine
KW  - Treatment Outcome
KW  - Sex Characteristics
KW  - Women
KW  - Interleukin-1beta
KW  - Neuroimaging
KW  - methamphetamine-use disorder
KW  - inflammation, brain
KW  - brain function
KW  - limbic connectivity
TI  - Sex differences in inflammation and brain function in methamphetamine use disorder
Y1  - 2024
L2  - https://digitalcollections.ohsu.edu/record/43552/files/ResearchWeek.2024.Sonnon.Alea.pdf
LK  - https://digitalcollections.ohsu.edu/record/43552/files/ResearchWeek.2024.Sonnon.Alea.pdf
UR  - https://digitalcollections.ohsu.edu/record/43552/files/ResearchWeek.2024.Sonnon.Alea.pdf
ER  -